Effectiveness of medication self-management, self-monitoring and a lifestyle intervention on hypertension in poorly controlled patients: The MEDICHY randomized trial

• Published in: Frontiers in cardiovascular medicine 2024-05, Vol.11, p.1355037-1355037
• Main Authors: Unda Villafuerte, Fabián, Llobera Cànaves, Joan, Estela Mantolan, Andreu, Bassante Flores, Patricia, Rigo Carratalà, Fernando, Requena Hernández, Ana, Oliver Oliver, Bartolomé, Pou Bordoy, Joan, Moreno Sancho, María Lucía, Leiva, Alfonso, Lorente Montalvo, Patricia
• Format: Article
• Language: English
• Subjects: blood pressure; Cardiovascular Medicine; hypertension; primary care; randomized trial; self-monitoring
• ISSN: 2297-055X; 2297-055X
• DOI: 10.3389/fcvm.2024.1355037

Uncontrolled hypertension is a common problem worldwide, despite the availability of many effective antihypertensive drugs and lifestyle interventions. We assessed the efficacy of a multi-component intervention in individuals with uncontrolled hypertension in a primary care setting. This study was a randomized, multicenter, parallel, two-arm, single-blind controlled trial performed in primary healthcare centers in Mallorca (Spain). All participants were 35 to 75-years-old and had poorly controlled hypertension. Patients were randomly assigned in a 1:1 ratio to a control group (usual care) or an intervention group (self-monitoring of blood pressure, self-titration of hypertensive medications, dietary interventions, and physical activity interventions). The primary outcome was decrease in the mean SBP at 6 months relative to baseline. A total of 153 participants were randomized to an intervention group (77) or a control group (76). After 6 months, the intervention group had a significantly lower systolic blood pressure (135.1 mmHg [±14.8] 142.7 mmHg [±15.0], adjusted mean difference: 8.7 mmHg [95% CI: 3.4, 13.9],