Bullous Pyoderma Gangrenosum in a Patient with Acute Myelogenous Leukemia as a Pathergic Reaction after Bone Marrow Biopsy

A 59-year-old male patient presented with a wound over the sacral region on a bone marrow biopsy puncture that had been present for 3 weeks (Figure 1). There was an ulceration of 6x4 cm with a bullous margin. Bullous pyoderma gangrenosum (PG) was diagnosed by the dermatology consultant. Histopatholo...

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Bibliographic Details
Published in:Turkish journal of haematology 2017-12, Vol.34 (4), p.350-351
Main Authors: Efe İris, Nur, Diz-Küçükkaya, Reyhan, Arat, Mutlu, Eriş, Zahide
Format: Article
Language:English
Subjects:
acute myelogenous leukemia
Biopsy
Bone marrow
bullous pyoderma gangrenosum
Images in Hematology
Leukemia
pathergy
Tıp
Ulcers
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Summary:A 59-year-old male patient presented with a wound over the sacral region on a bone marrow biopsy puncture that had been present for 3 weeks (Figure 1). There was an ulceration of 6x4 cm with a bullous margin. Bullous pyoderma gangrenosum (PG) was diagnosed by the dermatology consultant. Histopathologic examination of the biopsy specimen from the ulcer showed necrosis with an underlying mixed inflammatory cell infiltration within the dermis extending to the subcutis. Cultures of skin biopsies were negative for bacteria, fungi, and atypical mycobacteria. A bone marrow biopsy showed acute myelogenous leukemia (AML) transformed from myelodysplastic syndrome.
ISSN:1300-7777
1308-5263
DOI:10.4274/tjh.2016.0096