Triglyceride–glucose index (TyG index) is a predictor of incident colorectal cancer: a population-based longitudinal study

Background Colorectal cancer (CRC), which is related with insulin resistance, is a one of the most common cancers. Triglyceride-glucose index (TyG index) was made for a marker of insulin resistance. We conducted the investigation of association between TyG index and incident CRC. Methods We examined...

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Bibliographic Details
Published in:BMC endocrine disorders 2020-07, Vol.20 (1), p.1-113, Article 113
Main Authors: Okamura, Takuro, Hashimoto, Yoshitaka, Hamaguchi, Masahide, Obora, Akihiro, Kojima, Takao, Fukui, Michiaki
Format: Article
Language:English
Subjects:
Alcohol
Blood pressure
Blood tests
Body mass index
Cancer
Cardiovascular disease
Cell adhesion & migration
Cholesterol
Cohort analysis
Cohort study
Colorectal cancer
Colorectal carcinoma
Creatinine
Dextrose
Diabetes
Diagnosis
Epidemiology
Fasting
Gene expression
Glucose
Hospitals
Insulin
Insulin resistance
Insulin-like growth factors
Laboratory testing
Longitudinal studies
Metabolism
Oncology, Experimental
Pathogenesis
Plasma
Population studies
Population-based studies
Questionnaires
Risk factors
Studies
Triglycerides
TyG index
Type 2 diabetes
Variance analysis
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Summary:Background Colorectal cancer (CRC), which is related with insulin resistance, is a one of the most common cancers. Triglyceride-glucose index (TyG index) was made for a marker of insulin resistance. We conducted the investigation of association between TyG index and incident CRC. Methods We examined the affect of TyG index on incident CRC in this historical cohort study of 27,944 (16,454 men and 11,490 women) participants. TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. The impact of TyG index on incident CRC was investigated using Cox proportional hazard models, adjusting for sex, age, body mass index, smoking status, alcohol consumption, exercise, systolic blood pressure and creatinine. The covariate-adjusted receiver operating characteristic (ROC) curve calculated the area under the curve (AUC) and cut-off value of TyG index for the incidence of CRC. Results During the median 4.4-year follow-up, 116 participants were diagnosed as CRC. The cumulative incidence rate of CRC were 0.4%. In Cox proportional hazard model, the HRs of TyG index were 1.38 (95% Confidence interval (CI), 1.00–1.91, p = 0.049) after adjusting for covariates. In the covariate-adjusted ROC curve analysis, the cut-off value of TyG index for incident CRC was 8.272 (AUC 0.687 (95%CI, 0.637–737, sensitivity = 0.620, specificity = 0.668, p 
ISSN:1472-6823
1472-6823
DOI:10.1186/s12902-020-00581-w