Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review

Leishmaniases and chronic inflammatory diseases are the cause of millions of deaths in the world each year. The treatment of leishmaniasis is facing serious drawbacks particularly due to the limited number of effective medicines, the resistance, and the toxicity of available drugs. On the other hand...

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Bibliographic Details
Published in:Natural products and bioprospecting 2019-10, Vol.9 (5), p.311-328
Main Author: Toghueo, Rufin Marie Kouipou
Format: Article
Language:English
Subjects:
Anti-inflammatory
Anti-inflammatory agents
Anti-leishmanial
Bioactive compounds
Bioactive metabolites
Biocompatibility
Biomedical and Life Sciences
Bioorganic Chemistry
Disorders
Drug development
Drugs
Endophytes
Food Science
Inflammatory diseases
Leishmaniasis
Life Sciences
Medicinal Chemistry
Metabolites
Pharmacology/Toxicology
Plant Biochemistry
Plant Sciences
Review
Reviews
Side effects
Toxicity
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Summary:Leishmaniases and chronic inflammatory diseases are the cause of millions of deaths in the world each year. The treatment of leishmaniasis is facing serious drawbacks particularly due to the limited number of effective medicines, the resistance, and the toxicity of available drugs. On the other hand, many drugs are used for the management of inflammatory disorders. However, the most commonly prescribed although efficient is highly toxic with multiples side effects. New leads compounds for the development of new anti-leishmanial and anti-inflammatory drugs are needed. Over the past decade, several studies on the potential of endophytes to produce bioactive metabolites have been reported. We are presenting in the present review the status of research from 2000 to 2019 on the anti-leishmanial and anti-inflammatory metabolites isolated from endophytes from diverse habitats. An emphasis was put on existing gaps in the literature to inspire and guide future investigations. We hope that this review will help accelerate the drug discovery against leishmaniases and inflammation-associated disorders. Graphic Abstract
ISSN:2192-2195
2192-2209
DOI:10.1007/s13659-019-00220-5