Alkaloids with Their Protective Effects Against Aβ25-35-Induced PC-12 Cell Injury from the Tubers of Pinellia pedatisecta Schott

Seven new alkaloids [1, (±)-2, (±)-3, 4, and 5] and one new natural product (6), along with eight known analogues, were isolated from the tubers of Pinellia pedatisecta Schott. Their structures were determined by a comprehensive analysis of spectroscopic data, including HRESIMS, and electronic circu...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2024-10, Vol.29 (21), p.5059
Main Authors: Chen, Xu, Cao, Yangang, Ye, Kaili, Liu, Yanling, Chi, Fangge, Niu, Ying, Lu, Di, Zhao, Bingxian, Chen, Lan, Zheng, Xiaoke, Feng, Weisheng
Format: Article
Language:English
Subjects:
alkaloids
Alzheimer's disease
Araceae
PC-12 cell injury
Pinellia pedatisecta Schott
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Summary:Seven new alkaloids [1, (±)-2, (±)-3, 4, and 5] and one new natural product (6), along with eight known analogues, were isolated from the tubers of Pinellia pedatisecta Schott. Their structures were determined by a comprehensive analysis of spectroscopic data, including HRESIMS, and electronic circular dichroism (ECD). In addition, the results of the bioactivity evaluation showed that compounds (±)-3, 6, and 9 exhibited significantly protective effects against Aβ25-35-induced PC-12 cell injury and ameliorated cell viabilities by decreasing the levels of the reactive oxidative species (ROS) and mitochondrial membrane potential (MMP).
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29215059