TARGET based m6A methylation-related genes predict prognosis relapsed B-cell acute lymphoblastic leukemia

PurposeThe current study aims to investigate the significance of N6-methyladenosine (m6A) methylationrelated genes in the clinical prognosis of childhood relapsed B-cell acute lymphoblastic leukemia (B-ALLL) patient.MethodsTranscriptome data and corresponding clinical data on m6A methylation-related...

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Bibliographic Details
Published in:BMC pediatrics 2024-09, Vol.24 (1), p.1-7, Article 574
Main Authors: Qiu, Kun-yin, Liao, Xiong-yu, Fang, Jian-pei, Zhou, Dun-hua
Format: Article
Language:English
Subjects:
Biomarkers
Cancer
Children
Gene expression
Genomics
Leukemia
m6A methylation-related genes
Medical prognosis
Pediatrics
Prognosis
Relapsed B-ALL
Software
Survival analysis
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Summary:PurposeThe current study aims to investigate the significance of N6-methyladenosine (m6A) methylationrelated genes in the clinical prognosis of childhood relapsed B-cell acute lymphoblastic leukemia (B-ALLL) patient.MethodsTranscriptome data and corresponding clinical data on m6A methylation-related genes (including 20 genes) were obtained from the Therapeutically Applicable Research To Generate Effective Treatments (TARGET) database.ResultsThe bone marrow (BM) samples of 134 newly diagnosed (naive) and 116 relapsed B-ALL from TARGET were enrolled in the current study. Three genes (FTO, HNRNPC, RBM15B) showed significant up-regulation in relapsed B-ALL compared with that in naive B-ALL.The three genes had a significantly worse survival (P 
ISSN:1471-2431
1471-2431
DOI:10.1186/s12887-024-05053-x