Effect of 4-Week Consumption of Soy Kori-tofu on Cardiometabolic Health Markers: A Double-Blind Randomized Controlled Cross-Over Trial in Adults with Mildly Elevated Cholesterol Levels

Kori-tofu is a frozen soy tofu, and soy consumption is associated with positive effects on cardiometabolic health markers. We aimed to assess the potential of Kori-tofu to improve cardiometabolic health outcomes in humans by repetitive daily consumption. In a double-blind randomized controlled cross...

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Bibliographic Details
Published in:Nutrients 2022-12, Vol.15 (1), p.49
Main Authors: van den Belt, Maartje, van der Haar, Sandra, Oosterink, Els, van Loenhout, Tom, Ishiguro, Takahiro, Esser, Diederik
Format: Article
Language:English
Subjects:
Acids
Adiponectin
Bile
Blood pressure
Body mass index
Bread
cardiometabolic risk factors
Cholesterol
Clinical trials
Consumption
Crossovers
Diabetes
Diet
Double-blind studies
Food
Glucose
glucose metabolism
Glycosylated hemoglobin
Health aspects
Hemoglobin
High density lipoprotein
Insulin resistance
Intervention
Kori-tofu protein
LDL cholesterol
Lipids
Low density lipoprotein
Low density lipoproteins
Meta-analysis
Metabolism
Nutrition research
Peptides
Plant-based beverages
Proteins
Soy products
soy protein
Soybeans
Tofu
total cholesterol
Type 2 diabetes
Whey protein
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Summary:Kori-tofu is a frozen soy tofu, and soy consumption is associated with positive effects on cardiometabolic health markers. We aimed to assess the potential of Kori-tofu to improve cardiometabolic health outcomes in humans by repetitive daily consumption. In a double-blind randomized controlled cross-over trial, 45 subjects aged 40-70 years with (mildly) elevated cholesterol levels, received a four week Kori-tofu intervention or whey protein control intervention with a four week wash-out period in between. Cardiometabolic biomarkers were measured before and after both interventions. A significant decrease in total, low-density lipids (LDL), and high-density lipids (HDL) cholesterol, Hemoglobin A1c (HbA1c), fructosamine and systolic blood pressure was observed within the Kori-tofu intervention. However, many of these findings were also observed in the control intervention. Only adiponectin changes were different between treatments but did not change significantly within interventions. Improvements in cardiometabolic markers within the Kori-tofu intervention point toward potential beneficial health effects. Due to the lack of significant effects as compared to control, there is, however, currently no substantiating evidence to claim that Kori-tofu has beneficial effects on cardiometabolic health.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15010049