Production of bioactive β-carotene by the endophytic bacterium Citricoccus parietis AUCs with multiple in vitro biological potentials

Although microalgae and plants are traditionally used for obtaining natural pigments, overexploitation and overharvesting threaten them. Bacteria represent a superior alternative for the production of pigments due to their ability to produce greater amounts in a short time without seasonal restricti...

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Bibliographic Details
Published in:Microbial cell factories 2023-05, Vol.22 (1), p.90-9, Article 90
Main Authors: Hagaggi, Noura Sh A, Abdul-Raouf, Usama M
Format: Article
Language:English
Subjects:
Antibacterial
Antidiabetic
Antidiabetics
Antioxidant
Antioxidants
Antioxidants - pharmacology
Bacteria
Bacteriology
beta Carotene
Biodegradation
Biological activity
Biomass
Biomedical materials
Carotene
Carotenoids
Carotenoids - chemistry
Chromatography
Citricoccus parietis
Cosmetics
Diabetes mellitus
Endophytes
In vivo methods and tests
Micrococcaceae
Overexploitation
Pigment
Pigments
Reagents
Yeast
β-Carotene
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Summary:Although microalgae and plants are traditionally used for obtaining natural pigments, overexploitation and overharvesting threaten them. Bacteria represent a superior alternative for the production of pigments due to their ability to produce greater amounts in a short time without seasonal restrictions; furthermore, bacterial pigments have a wide range of uses and are safe and biodegradable. This study is the first on the production of ß-carotene as a promising bioactive agent from endophytic bacteria. The yellow pigment produced by the endophytic bacterium Citricoccus parietis AUCs (NCBI accession number: OQ448507.1) was extracted by methanol and then purified and identified. One band was obtained by TLC analysis, which was identified as ß-carotene based on its spectroscopic and chromatographic characteristics. The pigment exhibited remarkable antibacterial, antioxidant and antidiabetic activities. This research may serve as a valuable starting point for exploiting C. parietis AUCs as a potent source of ß-carotene for biomedical therapies. To validate the findings of this research, in vivo studies must be performed.
ISSN:1475-2859
1475-2859
DOI:10.1186/s12934-023-02108-z