Association of Maternal Microbiota and Diet in Cord Blood Cytokine and Immunoglobulin Profiles

Mothers confer natural passive immunization to their infants through the transplacental pathway during the gestation period. The objective of the present study was to establish at birth the maternal and cord plasma concentration and relationship of immunoglobulins (Igs), cytokines (CKs), and adipoki...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-02, Vol.22 (4), p.1778
Main Authors: Rio-Aige, Karla, Azagra-Boronat, Ignasi, Massot-Cladera, Malén, Selma-Royo, Marta, Parra-Llorca, Anna, González, Sonia, García-Mantrana, Izaskun, Castell, Margarida, Rodríguez-Lagunas, María J, Collado, María Carmen, Pérez Cano, Francisco José
Format: Article
Language:English
Subjects:
Adipokines - blood
Adipokines - immunology
breast milk
cytokine
Cytokines - blood
Cytokines - immunology
Diet
enterotype
Feces - microbiology
Female
Fetal Blood - chemistry
Fetal Blood - immunology
Humans
Immunity
immunoglobulin
Immunoglobulins - blood
Immunoglobulins - immunology
Infant, Newborn
Male
Microbiota
Nutritional Status
Pregnancy
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Summary:Mothers confer natural passive immunization to their infants through the transplacental pathway during the gestation period. The objective of the present study was to establish at birth the maternal and cord plasma concentration and relationship of immunoglobulins (Igs), cytokines (CKs), and adipokines. In addition, the impact of the maternal microbiota and diet was explored. The plasma profile of these components was different between mothers and babies, with the levels of many CKs, IgM, IgG2a, IgE, IgA, and leptin significantly higher in mothers than in the cord sample. Moreover, the total Igs, all IgG subtypes, IgE, and the Th1/Th2 ratio positively correlated in the mother-infant pair. Maternal dietary components such as monounsaturated fatty acids-polyunsaturated fatty acids and fiber were positively associated with some immune factors such as IgA in cord samples. The microbiota composition clustering also influenced the plasma profile of some factors (i.e., many CKs, some Ig, and adiponectin). In conclusion, we have established the concentration of these immunomodulatory factors in the maternal-neonatal pair at birth, some positive associations, and the influence of maternal diet and the microbiota composition, suggesting that the immune status during pregnancy, in terms of CKs and Igs levels, can influence the immune status of the infant at birth.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22041778