Different perception of dry eye symptoms between patients with and without primary Sjogren’s syndrome

Here, we investigated the different perception of dry eye symptoms between in patients with and without primary Sjogren’s syndrome (pSS). In this study, 221 patients with dry eye disease (DED) without pSS (non-SS DED group) and 55 patients with DED with pSS (SS DED group) were included. The ocular d...

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Bibliographic Details
Published in:Scientific reports 2022-02, Vol.12 (1), p.2172-2172, Article 2172
Main Authors: Kim, Minjeong, Chun, Yeoun Sook, Kim, Kyoung Woo
Format: Article
Language:English
Subjects:
692/1807/1482
692/699/3161
Collaboration
Cornea
Demographics
Dry Eye Syndromes - diagnosis
Dry Eye Syndromes - physiopathology
Eye
Eye diseases
Female
Females
Humanities and Social Sciences
Humans
Inflammation
Male
Middle Aged
multidisciplinary
Patients
Perception
Science
Science (multidisciplinary)
Severity of Illness Index
Sjogren's syndrome
Sjogren's Syndrome - diagnosis
Sjogren's Syndrome - physiopathology
Tears
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Summary:Here, we investigated the different perception of dry eye symptoms between in patients with and without primary Sjogren’s syndrome (pSS). In this study, 221 patients with dry eye disease (DED) without pSS (non-SS DED group) and 55 patients with DED with pSS (SS DED group) were included. The ocular discomfort was evaluated using ocular surface disease index (OSDI) questionnaire and patients were further divided into 3 severity subgroups according to OSDI scores. The OSDI score was higher in the non-SS DED group even after matching corneal erosion scores despite the ocular surface erosions and tear deficiency was worse in the SS DED group. The corneal sensitivity was nearly normal in both groups without inter-group difference (Non-SS DED group: 5.82 ± 0.54 cm, SS DED group: 5.90 ± 0.29 cm, p  = 0.217). Moreover, all clinical parameters were not significantly correlated with OSDI scores in both non-SS DED group and SS DED group. In the mild and severe OSDI subgroups, the ocular surface erosions and tear deficiency were worse in the SS DED group whereas the OSDI scores were not different between groups. In conclusion, clinicians should be aware that pSS patients may complain less of their discomfort unlike their actual severe status of DED.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-06191-x