Efficacy of interleukin-17 inhibitors on radiographic progression in psoriatic arthritis: A systematic review and meta-analysis

The therapeutic effects of IL-17 inhibitors on structural damage were not consistent over multiple trials. [...]a systematic review and meta-analysis of the available randomized controlled trials (RCTs) was conducted to quantify the overall effect of IL-17 inhibitors on structural damage in PsA. At...

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Bibliographic Details
Published in:Chinese medical journal 2024-02, Vol.137 (4), p.473-475
Main Authors: Jiang, Han-Lei, Du, Yu, Tong, Qiang, Dai, Sheng-Ming
Format: Article
Language:English
Subjects:
Antirheumatic Agents - therapeutic use
Arthritis, Psoriatic - diagnostic imaging
Arthritis, Psoriatic - drug therapy
Correspondence
Cytokines
Drug dosages
Humans
Immunology
Interleukin Inhibitors
Interleukin-17
Interleukin-23 - therapeutic use
Psoriasis
Psoriatic arthritis
Rheumatology
Systematic review
Tumor Necrosis Factor-alpha - therapeutic use
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Summary:The therapeutic effects of IL-17 inhibitors on structural damage were not consistent over multiple trials. [...]a systematic review and meta-analysis of the available randomized controlled trials (RCTs) was conducted to quantify the overall effect of IL-17 inhibitors on structural damage in PsA. At week 24, 1409/1636 (86.1%) of the patients receiving IL-17 inhibitors for PsA were considered radiographic non-progressors compared with 648/850 (76.2%) of the patients receiving placebo (risk ratio [RR] 1.13, 95% CI 1.08 to 1.18, P
ISSN:0366-6999
2542-5641
2542-5641
DOI:10.1097/CM9.0000000000002860