Conformational dynamics and kinetics of protein interactions by nuclear magnetic resonance

•The importance of dynamics in proteins complexes formation is discussed.•Specific and nonspecific interactions in recognition.•Conformational ensemble in the conformational selection mechanisms. Structural information of protein complexes is fundamental for the rational drug design and improvement...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Magnetic Resonance Open 2023-06, Vol.14-15, p.100093, Article 100093
Main Authors: Moraes, Adolfo H., Valente, Ana Paula
Format: Article
Language:English
Subjects:
Allostery
Dynamics
NMR
Protein complexes
Recognition
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•The importance of dynamics in proteins complexes formation is discussed.•Specific and nonspecific interactions in recognition.•Conformational ensemble in the conformational selection mechanisms. Structural information of protein complexes is fundamental for the rational drug design and improvement of vaccines and biosensors. Also, protein misassembly can have severe biological consequences. Here we discuss the challenges of studying protein complexes and show examples of systems characterized using NMR. [Display omitted]
ISSN:2666-4410
2666-4410
DOI:10.1016/j.jmro.2023.100093