Hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats

This study evaluated the hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of root-bark, in alloxan-induced hyperglycemic rats. The extract of root-bark was prepared using a cold maceration method with 80% methanol and concentrated at 40°C...

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Bibliographic Details
Published in:Current issues in pharmacy and medical sciences 2019-09, Vol.32 (3), p.125-129
Main Authors: Onoja, Samuel O., Daniel-Igwe, Gloria, Ejiofor, Emmanuel, Mbakwe, Christiana C., Okeke, Ugochuhwu S., Ezeja, Maxwell I., Omeh, Yusuf N., Asuzu, Isaac U.
Format: Article
Language:English
Subjects:
antioxidant
hepatoprotective
Lipid peroxidation
lipid profile
Lipids
Liver
nephroprotective
Paullinia pinnata
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Summary:This study evaluated the hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of root-bark, in alloxan-induced hyperglycemic rats. The extract of root-bark was prepared using a cold maceration method with 80% methanol and concentrated at 40°C in hot air oven. The extract was administered once daily per os at 50, 100 and 200 mg/kg for 21 consecutive days. Distilled water (5 mL/kg) and glibenclamide (2 mg/kg) were used as the vehicle and reference standard, respectively. The serum lipid profile, markers of liver and kidney functions, antioxidant status (malondialdehyde level, superoxide dismutase and catalase activities), histopathological changes in liver and kidney were examined 24h after the last treatment on day 21. The extract reduced serum lipid profile, markers of liver and kidney functions of treated rats relative to vehicle-treated rats. The superoxide dismutase and catalase activities of the extract treated rats were also elevated relative to the vehicle-treated rats. The extract reversed liver and kidney injuries induced by alloxan in the treated rats. This study provides some basic information which suggest that could be effective in managing diabetic complications.
ISSN:2084-980X
2300-6676
DOI:10.2478/cipms-2019-0023