Mini review: human clinical studies of stem cell therapy in keratoconus

Treatment of keratoconus is one of the most interesting research fields for researchers in the world. Regenerative medicine based on human stem cells in the treatment of keratoconus has recently received attention. Despite extensive laboratory and animal studies in regenerative medicine of cornea, t...

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Bibliographic Details
Published in:BMC ophthalmology 2024-01, Vol.24 (1), p.35-8, Article 35
Main Authors: Ahadi, Masoumeh, Ramin, Shahrokh, Abbasi, Ali, Tahmouri, Hanieh, Hosseini, Seyed Bagher
Format: Article
Language:English
Subjects:
Animals
Antibiotics
Body fat
Bone marrow
Care and treatment
Cell culture
Cell therapy
Cell- and Tissue-Based Therapy
Clinical trials
Collagen
Cornea
Extracellular matrix
Humans
Keratoconus
Keratocytes
Lasers
Mesenchymal Stem Cells
Regenerative Medicine
Review
Stem cell research
Stem Cell Therapy
Stem Cells
Stroma
Surgery
Tissue engineering
Transplantation
Transplants & implants
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Summary:Treatment of keratoconus is one of the most interesting research fields for researchers in the world. Regenerative medicine based on human stem cells in the treatment of keratoconus has recently received attention. Despite extensive laboratory and animal studies in regenerative medicine of cornea, there are limited clinical studies in keratoconus. These studies showed promising results of stem cell therapy. In initial studies, the transplantation of these cells into stroma was associated with increased vision and improved corneal parameters without side effects. In this article, we tried to review different aspects of keratoconus stem cell therapy, including cell extraction and culture, surgical procedure, effectiveness and safety of this method in human clinical studies.
ISSN:1471-2415
1471-2415
DOI:10.1186/s12886-024-03297-w