Generation of an induced pluripotent stem cell line (ZZUi020-A) from a patient with Parkinson’s disease harboring the intermediate-length GGC repeat expansions in the NOTCH2NLC gene

Here, we describe the generation of an induced pluripotent stem cell (iPSC) line, from a female patient diagnosed with Parkinson’s disease (PD). The patient carries a heterozygous intermediate-length GGC repeat expansions mutation in the NOTCH2NLC gene. Skin fibroblasts were reprogrammed using the n...

Full description

Saved in:
Bibliographic Details
Published in:Stem cell research 2021-04, Vol.52, p.102257-102257, Article 102257
Main Authors: Fan, Yu, Liu, Fen, Fan, Li-yuan, Mao, Cheng-yuan, Liu, Han, Zhang, Chan, Yuan, Yan-peng, Yang, Jing, Wang, Yan-lin, Liu, Yu-tao, Shi, Chang-he, Xu, Yu-ming
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c462t-7ae9b3f2ca1d25b41a19765598601f81cd8d4b1fce4acf3e1da4d2c4d65597743
cites cdi_FETCH-LOGICAL-c462t-7ae9b3f2ca1d25b41a19765598601f81cd8d4b1fce4acf3e1da4d2c4d65597743
container_end_page 102257
container_issue
container_start_page 102257
container_title Stem cell research
container_volume 52
creator Fan, Yu
Liu, Fen
Fan, Li-yuan
Mao, Cheng-yuan
Liu, Han
Zhang, Chan
Yuan, Yan-peng
Yang, Jing
Wang, Yan-lin
Liu, Yu-tao
Shi, Chang-he
Xu, Yu-ming
description Here, we describe the generation of an induced pluripotent stem cell (iPSC) line, from a female patient diagnosed with Parkinson’s disease (PD). The patient carries a heterozygous intermediate-length GGC repeat expansions mutation in the NOTCH2NLC gene. Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver Klf4, OCT3/4, SOX2 and c-MYC factors. The generated iPSC line (ZZUi020-A) presented with expression of common pluripotency markers, showed potential of differentiating into derivatives of the three germ layers, and displayed a normal karyotype. The clone ZZUi020-A is presented thereafter, it can be used to study the mechanisms underlying NOTCH2NLC-PD pathogenesis.
doi_str_mv 10.1016/j.scr.2021.102257
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_12b85f0e395b49979e4fcb23522bf1b1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1873506121001033</els_id><doaj_id>oai_doaj_org_article_12b85f0e395b49979e4fcb23522bf1b1</doaj_id><sourcerecordid>2493452116</sourcerecordid><originalsourceid>FETCH-LOGICAL-c462t-7ae9b3f2ca1d25b41a19765598601f81cd8d4b1fce4acf3e1da4d2c4d65597743</originalsourceid><addsrcrecordid>eNp9kUtuFDEQhlsIRELgAGyQl2HRg-1-i1U0giHSKGFBNtlYbrs846HHbmwPkF2uwUm4DyehejpkycoPffWXXV-WvWZ0wSir3-0WUYUFp5zhmfOqeZKdsrap86apiqfHfZFXtGYn2YsYd5RWHW_58-ykKGpel11xmv1egYMgk_WOeEOkI9bpgwJNxuEQ7OgTuERigj1RMAxksA7I-e3tjaWc5hdviQl-TyQZMWIif9i0JZ9l-Gpd9O7P_a9ItI0gI5CtDL0P1m1I2gK2SRD2oK1MkA_gNli3Wi1JgBFkIvBzlC7iqyKSx4Kr6y_LT_xqvSQbfPLL7JmRQ4RXD-tZdvPxAwL5-np1ubxY56qsecobCV1fGK4k07zqSyZZ19RV1bU1ZaZlSre67JlRUEplCmBalpqrUk9M05TFWXY552ovd2IMdi_DnfDSiuOFDxshQ7JqAMF431aGQtFho65rOiiN6nlRcd4b1jPMOp-zxuC_HSAmsbdxmqp04A9RcDRSVpyxGlE2oyr4GAOYx9aMism92Al0Lyb3YnaPNW8e4g89Dvax4p9sBN7PAODAvlsIGIHSULYNoBL-yP4n_i9kJMEC</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2493452116</pqid></control><display><type>article</type><title>Generation of an induced pluripotent stem cell line (ZZUi020-A) from a patient with Parkinson’s disease harboring the intermediate-length GGC repeat expansions in the NOTCH2NLC gene</title><source>BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS</source><creator>Fan, Yu ; Liu, Fen ; Fan, Li-yuan ; Mao, Cheng-yuan ; Liu, Han ; Zhang, Chan ; Yuan, Yan-peng ; Yang, Jing ; Wang, Yan-lin ; Liu, Yu-tao ; Shi, Chang-he ; Xu, Yu-ming</creator><creatorcontrib>Fan, Yu ; Liu, Fen ; Fan, Li-yuan ; Mao, Cheng-yuan ; Liu, Han ; Zhang, Chan ; Yuan, Yan-peng ; Yang, Jing ; Wang, Yan-lin ; Liu, Yu-tao ; Shi, Chang-he ; Xu, Yu-ming</creatorcontrib><description>Here, we describe the generation of an induced pluripotent stem cell (iPSC) line, from a female patient diagnosed with Parkinson’s disease (PD). The patient carries a heterozygous intermediate-length GGC repeat expansions mutation in the NOTCH2NLC gene. Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver Klf4, OCT3/4, SOX2 and c-MYC factors. The generated iPSC line (ZZUi020-A) presented with expression of common pluripotency markers, showed potential of differentiating into derivatives of the three germ layers, and displayed a normal karyotype. The clone ZZUi020-A is presented thereafter, it can be used to study the mechanisms underlying NOTCH2NLC-PD pathogenesis.</description><identifier>ISSN: 1873-5061</identifier><identifier>EISSN: 1876-7753</identifier><identifier>DOI: 10.1016/j.scr.2021.102257</identifier><identifier>PMID: 33626493</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><ispartof>Stem cell research, 2021-04, Vol.52, p.102257-102257, Article 102257</ispartof><rights>2021 The Author(s)</rights><rights>Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-7ae9b3f2ca1d25b41a19765598601f81cd8d4b1fce4acf3e1da4d2c4d65597743</citedby><cites>FETCH-LOGICAL-c462t-7ae9b3f2ca1d25b41a19765598601f81cd8d4b1fce4acf3e1da4d2c4d65597743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33626493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fan, Yu</creatorcontrib><creatorcontrib>Liu, Fen</creatorcontrib><creatorcontrib>Fan, Li-yuan</creatorcontrib><creatorcontrib>Mao, Cheng-yuan</creatorcontrib><creatorcontrib>Liu, Han</creatorcontrib><creatorcontrib>Zhang, Chan</creatorcontrib><creatorcontrib>Yuan, Yan-peng</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><creatorcontrib>Wang, Yan-lin</creatorcontrib><creatorcontrib>Liu, Yu-tao</creatorcontrib><creatorcontrib>Shi, Chang-he</creatorcontrib><creatorcontrib>Xu, Yu-ming</creatorcontrib><title>Generation of an induced pluripotent stem cell line (ZZUi020-A) from a patient with Parkinson’s disease harboring the intermediate-length GGC repeat expansions in the NOTCH2NLC gene</title><title>Stem cell research</title><addtitle>Stem Cell Res</addtitle><description>Here, we describe the generation of an induced pluripotent stem cell (iPSC) line, from a female patient diagnosed with Parkinson’s disease (PD). The patient carries a heterozygous intermediate-length GGC repeat expansions mutation in the NOTCH2NLC gene. Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver Klf4, OCT3/4, SOX2 and c-MYC factors. The generated iPSC line (ZZUi020-A) presented with expression of common pluripotency markers, showed potential of differentiating into derivatives of the three germ layers, and displayed a normal karyotype. The clone ZZUi020-A is presented thereafter, it can be used to study the mechanisms underlying NOTCH2NLC-PD pathogenesis.</description><issn>1873-5061</issn><issn>1876-7753</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9kUtuFDEQhlsIRELgAGyQl2HRg-1-i1U0giHSKGFBNtlYbrs846HHbmwPkF2uwUm4DyehejpkycoPffWXXV-WvWZ0wSir3-0WUYUFp5zhmfOqeZKdsrap86apiqfHfZFXtGYn2YsYd5RWHW_58-ykKGpel11xmv1egYMgk_WOeEOkI9bpgwJNxuEQ7OgTuERigj1RMAxksA7I-e3tjaWc5hdviQl-TyQZMWIif9i0JZ9l-Gpd9O7P_a9ItI0gI5CtDL0P1m1I2gK2SRD2oK1MkA_gNli3Wi1JgBFkIvBzlC7iqyKSx4Kr6y_LT_xqvSQbfPLL7JmRQ4RXD-tZdvPxAwL5-np1ubxY56qsecobCV1fGK4k07zqSyZZ19RV1bU1ZaZlSre67JlRUEplCmBalpqrUk9M05TFWXY552ovd2IMdi_DnfDSiuOFDxshQ7JqAMF431aGQtFho65rOiiN6nlRcd4b1jPMOp-zxuC_HSAmsbdxmqp04A9RcDRSVpyxGlE2oyr4GAOYx9aMism92Al0Lyb3YnaPNW8e4g89Dvax4p9sBN7PAODAvlsIGIHSULYNoBL-yP4n_i9kJMEC</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Fan, Yu</creator><creator>Liu, Fen</creator><creator>Fan, Li-yuan</creator><creator>Mao, Cheng-yuan</creator><creator>Liu, Han</creator><creator>Zhang, Chan</creator><creator>Yuan, Yan-peng</creator><creator>Yang, Jing</creator><creator>Wang, Yan-lin</creator><creator>Liu, Yu-tao</creator><creator>Shi, Chang-he</creator><creator>Xu, Yu-ming</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>202104</creationdate><title>Generation of an induced pluripotent stem cell line (ZZUi020-A) from a patient with Parkinson’s disease harboring the intermediate-length GGC repeat expansions in the NOTCH2NLC gene</title><author>Fan, Yu ; Liu, Fen ; Fan, Li-yuan ; Mao, Cheng-yuan ; Liu, Han ; Zhang, Chan ; Yuan, Yan-peng ; Yang, Jing ; Wang, Yan-lin ; Liu, Yu-tao ; Shi, Chang-he ; Xu, Yu-ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-7ae9b3f2ca1d25b41a19765598601f81cd8d4b1fce4acf3e1da4d2c4d65597743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fan, Yu</creatorcontrib><creatorcontrib>Liu, Fen</creatorcontrib><creatorcontrib>Fan, Li-yuan</creatorcontrib><creatorcontrib>Mao, Cheng-yuan</creatorcontrib><creatorcontrib>Liu, Han</creatorcontrib><creatorcontrib>Zhang, Chan</creatorcontrib><creatorcontrib>Yuan, Yan-peng</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><creatorcontrib>Wang, Yan-lin</creatorcontrib><creatorcontrib>Liu, Yu-tao</creatorcontrib><creatorcontrib>Shi, Chang-he</creatorcontrib><creatorcontrib>Xu, Yu-ming</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Stem cell research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fan, Yu</au><au>Liu, Fen</au><au>Fan, Li-yuan</au><au>Mao, Cheng-yuan</au><au>Liu, Han</au><au>Zhang, Chan</au><au>Yuan, Yan-peng</au><au>Yang, Jing</au><au>Wang, Yan-lin</au><au>Liu, Yu-tao</au><au>Shi, Chang-he</au><au>Xu, Yu-ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Generation of an induced pluripotent stem cell line (ZZUi020-A) from a patient with Parkinson’s disease harboring the intermediate-length GGC repeat expansions in the NOTCH2NLC gene</atitle><jtitle>Stem cell research</jtitle><addtitle>Stem Cell Res</addtitle><date>2021-04</date><risdate>2021</risdate><volume>52</volume><spage>102257</spage><epage>102257</epage><pages>102257-102257</pages><artnum>102257</artnum><issn>1873-5061</issn><eissn>1876-7753</eissn><abstract>Here, we describe the generation of an induced pluripotent stem cell (iPSC) line, from a female patient diagnosed with Parkinson’s disease (PD). The patient carries a heterozygous intermediate-length GGC repeat expansions mutation in the NOTCH2NLC gene. Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver Klf4, OCT3/4, SOX2 and c-MYC factors. The generated iPSC line (ZZUi020-A) presented with expression of common pluripotency markers, showed potential of differentiating into derivatives of the three germ layers, and displayed a normal karyotype. The clone ZZUi020-A is presented thereafter, it can be used to study the mechanisms underlying NOTCH2NLC-PD pathogenesis.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>33626493</pmid><doi>10.1016/j.scr.2021.102257</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1873-5061
ispartof Stem cell research, 2021-04, Vol.52, p.102257-102257, Article 102257
issn 1873-5061
1876-7753
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_12b85f0e395b49979e4fcb23522bf1b1
source BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS
title Generation of an induced pluripotent stem cell line (ZZUi020-A) from a patient with Parkinson’s disease harboring the intermediate-length GGC repeat expansions in the NOTCH2NLC gene
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T11%3A30%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Generation%20of%20an%20induced%20pluripotent%20stem%20cell%20line%20(ZZUi020-A)%20from%20a%20patient%20with%20Parkinson%E2%80%99s%20disease%20harboring%20the%20intermediate-length%20GGC%20repeat%20expansions%20in%20the%20NOTCH2NLC%20gene&rft.jtitle=Stem%20cell%20research&rft.au=Fan,%20Yu&rft.date=2021-04&rft.volume=52&rft.spage=102257&rft.epage=102257&rft.pages=102257-102257&rft.artnum=102257&rft.issn=1873-5061&rft.eissn=1876-7753&rft_id=info:doi/10.1016/j.scr.2021.102257&rft_dat=%3Cproquest_doaj_%3E2493452116%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c462t-7ae9b3f2ca1d25b41a19765598601f81cd8d4b1fce4acf3e1da4d2c4d65597743%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2493452116&rft_id=info:pmid/33626493&rfr_iscdi=true