Glochodpurnoid B from Glochidion puberum Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in Colorectal Cancer Cells

Glochidpurnoids A and B ( and ), two new coumaroyl or feruloyl oleananes, along with 17 known triterpenoids ( - ) were obtained from the stems and twigs of . Their structures were elucidated by extensive spectroscopic data analyses, chemical methods, and single crystal X-ray diffraction. All compoun...

Full description

Saved in:
Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-01, Vol.28 (2), p.511
Main Authors: Tian, Yang, Fan, Runzhu, Yin, Zhao, Huang, Yongping, Huang, Dong, Yuan, Fangyu, Yin, Aiping, Tang, Guihua, Pu, Rong, Yin, Sheng
Format: Article
Language:English
Subjects:
5-Fluorouracil
Acids
Angiogenesis
Apoptosis
Cancer therapies
Cell growth
Cell Line, Tumor
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - metabolism
Cytotoxicity
Drug dosages
Endoplasmic reticulum
Endoplasmic Reticulum Stress
Fluorouracil - pharmacology
Glochidion
Glochidion puberum
Humans
Malpighiales
Natural products
Single crystals
structural elucidation
triterpenoid
Triterpenoids
X-ray diffraction
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glochidpurnoids A and B ( and ), two new coumaroyl or feruloyl oleananes, along with 17 known triterpenoids ( - ) were obtained from the stems and twigs of . Their structures were elucidated by extensive spectroscopic data analyses, chemical methods, and single crystal X-ray diffraction. All compounds were screened for cytotoxicity against the colorectal cancer cell line HCT-116, and , , , , , and showed remarkable inhibitory activities (IC : 0.80-2.99 μM), being more active than the positive control 5-fluorouracil (5-FU). The mechanistic study of , the most potent compound, showed that it could induce endoplasmic reticulum (ER) stress-mediated apoptosis and improve the sensitivity of HCT-116 cells to 5-FU.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28020511