Pancytopenia associated with clonazepam

We report a case of a 48-year-old Chinese female with end-stage renal disease and chronic anemia on hemodialysis. Clonazepam was prescribed for myoclonus disorder two weeks prior to her hospitalization. Subsequently, she was hospitalized for neutropenic fever with thrombocytopenia and worsening anem...

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Bibliographic Details
Published in:Journal of hematology and oncology 2010-07, Vol.3 (1), p.24-24, Article 24
Main Authors: Bautista-Quach, Marnelli A, Liao, Yu-Min, Hsueh, Chung-Tsen
Format: Article
Language:English
Subjects:
Anemia
Anemia - complications
Anemia - drug therapy
Case Report
Case studies
Chronic kidney failure
Clonazepam
Clonazepam - adverse effects
Drug therapy
Female
GABA Modulators - adverse effects
Health aspects
Humans
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - drug therapy
Middle Aged
Pancytopenia
Pancytopenia - chemically induced
Pancytopenia - diagnosis
Treatment Outcome
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Summary:We report a case of a 48-year-old Chinese female with end-stage renal disease and chronic anemia on hemodialysis. Clonazepam was prescribed for myoclonus disorder two weeks prior to her hospitalization. Subsequently, she was hospitalized for neutropenic fever with thrombocytopenia and worsening anemia. Bone marrow examination demonstrated a markedly hypocellular marrow (10-20% total cellularity). Clonazepam was discontinued, with gradual improvement of thrombocytopenia, and neutropenia in 1-2 weeks. To our knowledge, this is the first reported case of pancytopenia associated with clonazepam. We recommend patients taking clonazepam to be monitored with regular complete blood count to check for clinically significant pancytopenia or thrombocytopenia.
ISSN:1756-8722
1756-8722
DOI:10.1186/1756-8722-3-24