Predictors and Outcomes of Heart Failure With Preserved Ejection Fraction in Patients With a Left Ventricular Ejection Fraction Above or Below 60

Background Although potential therapeutic candidates for heart failure with preserved ejection fraction (HFpEF) are emerging, it is still unclear whether they will be effective in patients with left ventricular ejection fraction (LVEF) of 60% or higher. Our aim was to identify the clinical character...

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Published in:Journal of the American Heart Association 2022-08, Vol.11 (15), p.e025300-e025300
Main Authors: Nakagawa, Akito, Yasumura, Yoshio, Yoshida, Chikako, Okumura, Takahiro, Tateishi, Jun, Yoshida, Junichi, Seo, Masahiro, Yano, Masamichi, Hayashi, Takaharu, Nakagawa, Yusuke, Tamaki, Shunsuke, Yamada, Takahisa, Kurakami, Hiroyuki, Sotomi, Yohei, Nakatani, Daisaku, Hikoso, Shungo, Sakata, Yasushi
Format: Article
Language:English
Subjects:
Aged, 80 and over
Female
Heart Failure
heart failure with preserved ejection fraction
Humans
left ventricular ejection fraction
Male
Original Research
Prognosis
prognostic factor
Prospective Studies
Stroke Volume - physiology
Ventricular Function, Left - physiology
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Summary:Background Although potential therapeutic candidates for heart failure with preserved ejection fraction (HFpEF) are emerging, it is still unclear whether they will be effective in patients with left ventricular ejection fraction (LVEF) of 60% or higher. Our aim was to identify the clinical characteristics of these patients with HFpEF by comparing them to patients with LVEF below 60%. Methods and Results From a multicenter, prospective, observational cohort (PURSUIT-HFpEF [Prospective Multicenter Obsevational Study of Patients with Heart Failure with Preserved Ejection Fraction]), we investigated 812 consecutive patients (median age, 83 years; 57% women), including 316 with 50% ≤ LVEF
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.122.025300