Elements of dissemination in cryptococcosis

As healthcare improves and our ability to support patients with compromised immune systems increases, such patients become more vulnerable to microbes in the environment. These include fungal pathogens such as , the primary cause of fungal meningitis and a top priority pathogen on the World Health O...

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Bibliographic Details
Published in:mBio 2024-12, Vol.15 (12), p.e0215523
Main Authors: Bednarek, Joseph M, Brown, Jessica C S
Format: Article
Language:English
Subjects:
Animals
cryptococcosis
Cryptococcosis - microbiology
Cryptococcus neoformans
Cryptococcus neoformans - pathogenicity
dissemination
fungal meningitis
Host-Microbial Interactions
Host-Pathogen Interactions
Humans
Lung - microbiology
Lung - pathology
medical mycology
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Summary:As healthcare improves and our ability to support patients with compromised immune systems increases, such patients become more vulnerable to microbes in the environment. These include fungal pathogens such as , the primary cause of fungal meningitis and a top priority pathogen on the World Health Organization fungal pathogen list. Like many other environmental pathogens, must adapt to and thrive in diverse environments in order to cause disease: (i) the environmental niche, (ii) the lungs following inhalation of infectious particles, (iii) the bloodstream and/or lymphatic system during dissemination, and (iv) the central nervous system (CNS), where it causes a deadly cryptococcal meningoencephalitis. Because CNS infection is the driver of mortality and the presenting illness, understanding the dissemination process from both host and fungal perspectives is important for treating these infections. In this review, we discuss the different stages of dissemination, how fungal cells interact with host cells during disease, and the ability to adapt to different environments within hosts.
ISSN:2150-7511
2150-7511
DOI:10.1128/mbio.02155-23