Highly efficient encapsulation of curcumin into and pH-controlled drug release from poly(ε-caprolactone) nanoparticles stabilized with a novel amphiphilic hyperbranched polyglycerol

The hardly water-soluble curcumin with low bioavailability was successfully encapsulated into biodegradable polymeric particles by nanoprecipitation. By using the more hydrophobic poly(s-caprolactone) (PCL) instead of poly(lactic-co-glycolic acid) 50:50 (PLGA) significantly increased drug load was a...

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Bibliographic Details
Published in:Express polymer letters 2020, Vol.14 (1), p.90-101
Main Authors: Nagy, N. Zs, Varga, Z., Mihaly, J., Kasza, Gy, Ivan, B., Kiss, E.
Format: Article
Language:English
Subjects:
Bioavailability
Biodegradability
Controlled release
curcumin
Design of experiments
Design optimization
Diameters
drug carrier
Drug carriers
Drug delivery systems
Encapsulation
Fourier transforms
Glycolic acid
hyperbranched polyglycerol
nanomaterials
Nanoparticles
Particle size
Pharmaceuticals
Polycaprolactone
Polyesters
Polyglycerols
Polymers
Potassium
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Summary:The hardly water-soluble curcumin with low bioavailability was successfully encapsulated into biodegradable polymeric particles by nanoprecipitation. By using the more hydrophobic poly(s-caprolactone) (PCL) instead of poly(lactic-co-glycolic acid) 50:50 (PLGA) significantly increased drug load was achieved. The stronger interaction between cur-cumin and PCL than PLGA was supported by Fourier-transform infrared spectroscopy (FTIR) measurements. As efficient colloid stabilizer, a novel amphiphilic polymer, hyperbranched polyglycerol with one long alkyl chain (C18-HbPG) was used which has better membrane affinity than the widely used Pluronics, and it enables further functionalization of the drug carrier as well. A Box-Behnken experimental design was applied to prepare and optimize the properties of curcumin loaded PCL nanoparticles (NPs) varying the initial drug load, composition of the organic phase and volume ratio of aqueous and organic phases. The volume of the organic phase was found to be the most relevant parameter for encapsulation, and it can be used to control the size and drug content of the NPs. The curcumin load of 10 w/w% of the NPs with diameter below 120 nm was observed in the optimal system. Cumulative controlled release of curcumin with strong pH-dependence into simulated gastric fluids with up to ~80% is found after 8-12 hours.
ISSN:1788-618X
1788-618X
DOI:10.3144/expresspolymlett.2020.8