β-Cyclodextrin Functionalized Au@Ag Core-Shell Nanoparticles: Plasmonic Sensors for Cysteamine and Efficient Nanocatalysts for Nitrobenzene-to-Aniline Conversion

• Published in: Biosensors (Basel) 2024-11, Vol.14 (11), p.544
• Main Authors: Rajamanikandan, Ramar, Sasikumar, Kandasamy, Ju, Heongkyu
• Format: Article
• Language: English
• Subjects: Analysis; Aniline; Aniline Compounds - chemistry; Aqueous solutions; beta-Cyclodextrins - chemistry; Bimetals; Biosensing Techniques; Biosensors; Catalysis; catalytic activity; Catalytic converters; Chromatography; Colorimetry; core-shell nanoparticles; Core-shell particles; Cyclodextrins; Cysteamine; Cysteamine - chemistry; Cysts; Drug screening; Electrons; Fourier transforms; Gold; Gold - chemistry; Human wastes; Humans; Limit of Detection; Metal Nanoparticles - chemistry; Nanocatalysis; Nanoparticles; Nitrobenzene; Nitrobenzenes; Plasmons; sensing ability; Sensors; Silver; Silver - chemistry; Spectrum analysis; Urine; β-Cyclodextrin
• ISSN: 2079-6374; 2079-6374
• DOI: 10.3390/bios14110544

We reported the gold/silver core-shell nanoparticles (Au @Ag NPs) functionalized with β-cyclodextrin (β-CD) as versatile nano-agents demonstrated for human urine-based biosensing of cysteamine and catalytic conversion from nitrobenzene (NB) to aniline. First, the hybrid bimetallic nanoparticles, i.e., β-CD-Au @Ag NPs, constituted a colorimetric sensing platform based on localized surface plasmons, enabling cysteamine (Cyst) to be detected in a remarkably rapid manner, i.e., within 2 min, which was greatly shortened in comparison with that of our previous report. This was due largely to use of β-CD being effectively replaceable by Cyst. The detection of Cyst was demonstrated using human urine specimens in the linear range of 25-750 nM with a limit of detection of 1.83 nM. Excellent specificity in detecting Cyst was also demonstrated against potential interfering molecules. Meanwhile, the β-CD-Au @Ag NPs were demonstrated as nanocatalysts for converting NB to aniline with efficiency enhanced by more than three-fold over the pure gold nanoparticles previously reported, due to the dual functions of the structural core-shell. The demonstrated versatile features of the hybrid nanoparticles can find applications in human urine-based biosensors for Cyst detection, and in the screening of Cyst-containing drugs, while detoxicating NB for ecological protection in aqueous media.