Hydrophilic Tetraphenylethene-Based Tetracationic Cyclophanes: NADPH Recognition and Cell Imaging With Fluorescent Switch

A hydrophilic TPE-based tetracationic cyclophane TPE-cyc was synthesized, which could capture intracellular Nicotinamide adenine dinucleotide phosphate and fuel the antioxidative ability of tumor cells to detoxify reactive oxygen species (ROS). Meanwhile, upon the reduction by cellular GSH, TPE-cyc...

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Bibliographic Details
Published in:Frontiers in chemistry 2021-12, Vol.9, p.817720-817720
Main Authors: Wu, Dan, Zhang, Zhankui, Yu, Xinyang, Bai, Bing, Qi, Shaolong
Format: Article
Language:English
Subjects:
Chemistry
fluorescent switch
host-guest complexation
NADPH recognition
tetracationic cyclophanes
tetraphenylethene
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Summary:A hydrophilic TPE-based tetracationic cyclophane TPE-cyc was synthesized, which could capture intracellular Nicotinamide adenine dinucleotide phosphate and fuel the antioxidative ability of tumor cells to detoxify reactive oxygen species (ROS). Meanwhile, upon the reduction by cellular GSH, TPE-cyc could light up tumor cells, acting as a GSH-responsive fluorescent switch to image cells with high resolution.
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2021.817720