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Synthesis, Cytotoxicity, and Photophysical Investigations of 2-Amino-4,6-diphenylnicotinonitriles: An Experimental and Theoretical Study
In this study, we present a comprehensive investigation of 2-amino-4,6-diphenylnicotinonitriles (APNs, - ), including their synthesis, cytotoxicity against breast cancer cell lines, and photophysical properties. Compound demonstrates exceptional cytotoxicity, surpassing the potency of Doxorubicin. T...
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Published in: | Molecules (Basel, Switzerland) Switzerland), 2024-04, Vol.29 (8), p.1808 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | In this study, we present a comprehensive investigation of 2-amino-4,6-diphenylnicotinonitriles (APNs,
-
), including their synthesis, cytotoxicity against breast cancer cell lines, and photophysical properties. Compound
demonstrates exceptional cytotoxicity, surpassing the potency of Doxorubicin. The fluorescence spectra of the synthesized
-
in different solvents reveal solvent-dependent shifts in the emission maximum values, highlighting the influence of the solvent environment on their fluorescence properties. A quantum chemical TD-DFT analysis provides insights into the electronic structure and fluorescence behavior of
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, elucidating HOMO-LUMO energy gaps, electronegativity values, and dipole moments, contributing to a deeper understanding of their electronic properties and potential reactivity. These findings provide valuable knowledge for the development of APNs (
-
) as fluorescent sensors and potential anticancer agents. |
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ISSN: | 1420-3049 1420-3049 |
DOI: | 10.3390/molecules29081808 |