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Synthesis, Cytotoxicity, and Photophysical Investigations of 2-Amino-4,6-diphenylnicotinonitriles: An Experimental and Theoretical Study

In this study, we present a comprehensive investigation of 2-amino-4,6-diphenylnicotinonitriles (APNs, - ), including their synthesis, cytotoxicity against breast cancer cell lines, and photophysical properties. Compound demonstrates exceptional cytotoxicity, surpassing the potency of Doxorubicin. T...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2024-04, Vol.29 (8), p.1808
Main Authors: Al-Ghamdi, Alwah R, Rahman, Shofiur, Al-Wabli, Reem I, Al-Mutairi, Maha S, Rahman, A F M Motiur
Format: Article
Language:English
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Summary:In this study, we present a comprehensive investigation of 2-amino-4,6-diphenylnicotinonitriles (APNs, - ), including their synthesis, cytotoxicity against breast cancer cell lines, and photophysical properties. Compound demonstrates exceptional cytotoxicity, surpassing the potency of Doxorubicin. The fluorescence spectra of the synthesized - in different solvents reveal solvent-dependent shifts in the emission maximum values, highlighting the influence of the solvent environment on their fluorescence properties. A quantum chemical TD-DFT analysis provides insights into the electronic structure and fluorescence behavior of - , elucidating HOMO-LUMO energy gaps, electronegativity values, and dipole moments, contributing to a deeper understanding of their electronic properties and potential reactivity. These findings provide valuable knowledge for the development of APNs ( - ) as fluorescent sensors and potential anticancer agents.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29081808