Efficacy of split-thickness skin graft combined with novel sheet-type reprocessed micronized acellular dermal matrix

Background Autologous split-thickness skin grafts (STSGs) remain the mainstay for treatment of large skin defects. Despite its many advantages, there exist critical disadvantages such as unfavorable scar and graft contracture. In addition, it cannot be used when structures such as tendons and bones...

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Bibliographic Details
Published in:BMC surgery 2022-10, Vol.22 (1), p.1-358, Article 358
Main Authors: Hahn, Hyung Min, Jeong, Yon Soo, Lee, Il Jae, Kim, Min Ji, Lim, Hyoseob
Format: Article
Language:English
Subjects:
Acellular dermal matrix
Antibiotics
Autografts
Bones
CGDerm Matrix
Debridement
Defects
Dermal substitute
Dermatologic agents
Dermatology
Diabetes
Diabetes mellitus
Diabetic foot
Drug therapy
Emergency medical care
Foot diseases
Formulae, receipts, prescriptions
Graft contracture
Grafting
Hematoma
Hospitals
Malignancy
Orthopedics
Patients
Plastic surgery
Reprocessed micronized ADM
Skin
Skin & tissue grafts
Skin grafts
Split-thickness skin graft
Surgical outcomes
Tendons
Thickness
Trauma
Ulcers
Wounds
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Summary:Background Autologous split-thickness skin grafts (STSGs) remain the mainstay for treatment of large skin defects. Despite its many advantages, there exist critical disadvantages such as unfavorable scar and graft contracture. In addition, it cannot be used when structures such as tendons and bones are exposed. To overcome these limitations, acellular dermal matrix (ADM) is widely used with STSG. CGDerm Matrix.sup.[R], which was recently developed, is a novel reprocessed micronized ADM (RMADM). In this study, outcomes of the combined application of RMADM and STSG on full-thickness wounds were analyzed. Methods Forty-one patients with full-thickness skin defects due to trauma, scar contracture release, and diabetic foot ulcers, who underwent STSGs, from January 2021 to July 2021, were retrospectively reviewed. The primary outcome of interest was skin loss rate, which was measured 14 days after surgery. Results The most common cause of skin defect was trauma (36 patients), diabetic foot (2 patients), scar contracture release (2 patients), and malignancy (1 patient). The average defect size was 109.6 cm.sup.2 (range, 8-450 cm.sup.2). The average skin loss rate was 9.1%, showing a graft take rate of > 90%. Conclusion The use of combined RMADM and STSG in full-thickness wound reconstruction provides stable and acceptable outcomes. The newly developed ADM can be a promising option in wound reconstruction. Keywords: Split-thickness skin graft, Acellular dermal matrix, Graft contracture, Dermal substitute, CGDerm Matrix, Reprocessed micronized ADM
ISSN:1471-2482
1471-2482
DOI:10.1186/s12893-022-01801-x