Influence of Experimental Conditions during Synthesis on the Physicochemical Properties of the SPION/Hydroxyapatite Nanocomposite for Magnetic Hyperthermia Application

In this work, we report on the fabrication of nanocomposites based on superparamagnetic iron oxide nanoparticles (SPIONs) in combination with hydroxyapatite (HAp) as a platform for drug delivery and magnetic hyperthermia application. First, the influence of experimental conditions such as co-precipi...

Full description

Saved in:
Bibliographic Details
Published in:Magnetochemistry 2022-08, Vol.8 (8), p.90
Main Authors: Thanh, Dinh Thi Mai, Phuong, Nguyen Thu, Hai, Do Thi, Giang, Ha Ngan, Thom, Nguyen Thi, Nam, Pham Thi, Dung, Nguyen Trung, Giersig, Michael, Osial, Magdalena
Format: Article
Language:English
Subjects:
Acids
Aqueous solutions
Cancer therapies
Composite materials
Drug delivery systems
Fever
Field strength
Fourier transforms
Hydroxyapatite
Hyperthermia
Iron oxides
Magnetic cores
Magnetic fields
magnetic hyperthermia
Magnetic properties
nanocomposite
Nanocomposites
Nanoparticles
Optimization
Polyvinyl alcohol
superparamagnetic iron oxide nanoparticles (SPIONs)
Synthesis
Temperature dependence
Wiring
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this work, we report on the fabrication of nanocomposites based on superparamagnetic iron oxide nanoparticles (SPIONs) in combination with hydroxyapatite (HAp) as a platform for drug delivery and magnetic hyperthermia application. First, the influence of experimental conditions such as co-precipitant, bath temperature, and pH on the morphology and magnetic properties of SPIONs was investigated. Then, the superparamagnetic particles were coated with the hydroxyapatite layer for further loading of anticancer drugs, determining the optimal thickness of the HAp shell. The composite was fabricated by the wet chemical process and was characterized by optimizing the experimental conditions of the wiring synthesis to obtain the superparamagnetic spherical material with a high HAp loading as a platform for drug uptake. SEM and TEM studies confirmed the round shape of the magnetic core up to 15 nm in size with a well-defined HAp shell. After checking the material’s superparamagnetic properties, the temperature dependence on time and alternating magnetic field strength was tested and optimized in hyperthermia experiments.
ISSN:2312-7481
2312-7481
DOI:10.3390/magnetochemistry8080090