Hyaluronic Acid Nanogels: A Promising Platform for Therapeutic and Theranostic Applications

Hyaluronic acid (HA) nanogels are a versatile class of nanomaterials with specific properties, such as biocompatibility, hygroscopicity, and biodegradability. HA nanogels exhibit excellent colloidal stability and high encapsulation capacity, making them promising tools for a wide range of biomedical...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutics 2023-11, Vol.15 (12), p.2671
Main Authors: Myint, Su Sundee, Laomeephol, Chavee, Thamnium, Sirikool, Chamni, Supakarn, Luckanagul, Jittima Amie
Format: Article
Language:English
Subjects:
Amino acids
Biomedical engineering
Cell growth
Chemical bonds
controlled release
Crosslinked polymers
Drug delivery systems
Drugs
Enzymes
Health aspects
Hyaluronic acid
hyaluronic acid nanogels
Ligands
Molecular weight
Motility
nanomedicine
Polyelectrolytes
Polymers
Review
Signal transduction
targeted delivery
Technology application
theranostics
Vehicles
Viscoelasticity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hyaluronic acid (HA) nanogels are a versatile class of nanomaterials with specific properties, such as biocompatibility, hygroscopicity, and biodegradability. HA nanogels exhibit excellent colloidal stability and high encapsulation capacity, making them promising tools for a wide range of biomedical applications. HA nanogels can be fabricated using various methods, including polyelectrolyte complexation, self-assembly, and chemical crosslinking. The fabrication parameters can be tailored to control the physicochemical properties of HA nanogels, such as size, shape, surface charge, and porosity, enabling the rational design of HA nanogels for specific applications. Stimulus-responsive nanogels are a type of HA nanogels that can respond to external stimuli, such as pH, temperature, enzyme, and redox potential. This property allows the controlled release of encapsulated therapeutic agents in response to specific physiological conditions. HA nanogels can be engineered to encapsulate a variety of therapeutic agents, such as conventional drugs, genes, and proteins. They can then be delivered to target tissues with high efficiency. HA nanogels are still under development, but they have the potential to become powerful tools for a wide range of theranostic or solely therapeutic applications, including anticancer therapy, gene therapy, drug delivery, and bioimaging.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15122671