Current asthma contributes as much as smoking to chronic bronchitis in middle age: a prospective population-based study

• Published in: International journal of chronic obstructive pulmonary disease 2016-01, Vol.11 (1), p.1911-1920
• Main Authors: Dharmage, Shyamali C, Perret, Jennifer L, Burgess, John A, Lodge, Caroline J, Johns, David P, Thomas, Paul S, Giles, Graham G, Hopper, John L, Abramson, Michael J, Walters, E Haydn, Matheson, Melanie C
• Format: Article
• Language: English
• Subjects: Adult; Age Factors; Age of Onset; allergy history; Asthma; Asthma - diagnosis; Asthma - epidemiology; Asthma - physiopathology; Bronchitis; Bronchitis, Chronic - diagnosis; Bronchitis, Chronic - epidemiology; Bronchitis, Chronic - physiopathology; Child; Childrens health; Chronic obstructive pulmonary disease; current asthma; Female; Follow-Up Studies; Humans; Investigations; Laboratories; Logistic Models; Longitudinal Studies; Lung - physiopathology; Male; Middle age; Multivariate Analysis; Non-obstructive chronic bronchitis; obstructive chronic bronchitis; Odds Ratio; Original Research; Outdoor air quality; personal smoking; Population-based studies; Prevalence; Prognosis; Prospective Studies; Questionnaires; Respiratory Sounds; Risk Factors; Smoking; Smoking - adverse effects; Smoking - epidemiology; Smoking - physiopathology; Spirometry; Surveys; Surveys and Questionnaires; Tasmania - epidemiology; Time Factors
• ISSN: 1178-2005; 1176-9106; 1178-2005
• DOI: 10.2147/COPD.S103908

Personal smoking is widely regarded to be the primary cause of chronic bronchitis (CB) in adults, but with limited knowledge of contributions by other factors, including current asthma. We aimed to estimate the independent and relative contributions to adult CB from other potential influences spanning childhood to middle age. The population-based Tasmanian Longitudinal Health Study cohort, people born in 1961, completed respiratory questionnaires and spirometry in 1968 (n=8,583). Thirty-seven years later, in 2004, two-thirds responded to a detailed postal survey (n=5,729), from which the presence of CB was established in middle age. A subsample (n=1,389) underwent postbronchodilator spirometry between 2006 and 2008 for the assessment of chronic airflow limitation, from which nonobstructive and obstructive CB were defined. Multivariable and multinomial logistic regression models were used to estimate relevant associations. The prevalence of CB in middle age was 6.1% (95% confidence interval [CI]: 5.5, 6.8). Current asthma and/or wheezy breathing in middle age was independently associated with adult CB (odds ratio [OR]: 6.2 [95% CI: 4.6, 8.4]), and this estimate was significantly higher than for current smokers of at least 20 pack-years (OR: 3.0 [95% CI: 2.1, 4.3]). Current asthma and smoking in middle age were similarly associated with obstructive CB, in contrast to the association between allergy and nonobstructive CB. Childhood predictors included allergic history (OR: 1.3 [95% CI: 1.1, 1.7]), current asthma (OR: 1.8 [95% CI: 1.3, 2.7]), "episodic" childhood asthma (OR: 2.3 [95% CI: 1.4, 3.9]), and parental bronchitis symptoms (OR: 2.5 [95% CI: 1.6, 4.1]). The strong independent association between current asthma and CB in middle age suggests that this condition may be even more influential than personal smoking in a general population. The independent associations of childhood allergy and asthma, though not childhood bronchitis, as clinical predictors of adult CB raise the possibility of some of this burden having originated in childhood.