Factors associated with treatment for latent tuberculosis in persons living with HIV/AIDS

• Published in: Cadernos de saúde pública 2015-12, Vol.31 (12), p.2505-2513
• Main Authors: Aquino, Daniela Silva de, Moura, Líbia Cristina Rocha Vilela, Maruza, Magda, Silva, Adriana Paula da, Ximenes, Ricardo Arraes de Alencar, Lacerda, Heloísa Ramos, Miranda Filho, Demócrito de Barros, Albuquerque, Maria de Fátima Pessoa Militão de
• Format: Article
• Language: English
• Subjects: Adult; Antitubercular Agents - therapeutic use; Female; HIV Infections - complications; Humans; Isoniazid - therapeutic use; Isoniazida; Latent Tuberculosis - complications; Latent Tuberculosis - diagnosis; Latent Tuberculosis - drug therapy; Latent Tuberculosis - epidemiology; Male; Prospective Studies; PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH; Risk Factors; Tuberculosis; VIH
• ISSN: 0102-311X; 1678-4464; 1678-4464; 0102-311X
• DOI: 10.1590/0102-311X00154614

The aim was to identify factors associated with non-initiation of prophylactic treatment of latent tuberculosis infection (LTBi) in persons living with HIV/AIDS (PLWA), based on a prospective cohort study of PLWA ≥ 18 years of age in two referral services for HIV/AIDS. Of the 232 patients eligible for treatment of LTBi, 69.8% initiated treatment. Following multivariate logistic regression analysis, only treatment in one of the two referral services was associated with non-initiation of treatment for LTBi (p < 0.001). TB incidence in the cohort was 0.6/100 person-years. TB incidence in patients that initiated treatment of LTBi was 0.4/100 person-years, compared to 1.2/100 person-years in those that did not initiate treatment, but the difference was not statistically significant. The study's most interesting finding was that the main factor associated with the likelihood of treatment for LTBi was the health service where the patient was treated.