In vitro bioactivity and cytotoxicity of chemically treated glass fibers

Samples of a commercial glass fibre were used to test the efficacy of a chemical sol-gel surface treatment to enhance their bioactivity. After treatment with tetraethoxysilane (TEOS), individual fibre samples were soaked in a simulated body fluid (SBF) solution, from which they were removed at inter...

Full description

Saved in:
Bibliographic Details
Published in:Materials research (São Carlos, São Paulo, Brazil) São Paulo, Brazil), 2004-12, Vol.7 (4), p.635-638
Main Authors: Andrade, Ângela Leão, Turchetti-Maia, Regina Maria de Marco, Lopes, Míriam Teresa Paz, Salas, Carlos Edmundo, Domingues, Rosana Zacarias
Format: Article
Language:English
Subjects:
bioactivity
chemical treatment
cytotoxicity
ENGINEERING, CHEMICAL
glass fiber
MATERIALS SCIENCE, MULTIDISCIPLINARY
METALLURGY & METALLURGICAL ENGINEERING
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Samples of a commercial glass fibre were used to test the efficacy of a chemical sol-gel surface treatment to enhance their bioactivity. After treatment with tetraethoxysilane (TEOS), individual fibre samples were soaked in a simulated body fluid (SBF) solution, from which they were removed at intervals of 5 and 10 days. Micrographs obtained by SEM analysis of samples chemically treated with TEOS revealed the formation of a hydroxyapatite (HA) coating layer after 5 days in the SBF solution. FTIR analyses confirmed that the coating layer had P-O vibration bands characteristic of HA. The in-vitro cytotoxicity was evaluated using a direct contact test, minimum essential medium elution test and MTT assay. Fibres immersed in SBF and their extracts exhibited lower cytotoxicity than the controls not subjected to immersion, suggesting that SBF treatment improves the biocompatibility of the fibre. 12 refs.
ISSN:1516-1439
1980-5373
1516-1439
DOI:10.1590/S1516-14392004000400019