Examination of the effect of treatment of severe early childhood caries and fluoride varnish applications on salivary oxidative stress biomarkers and antioxidants

• Published in: BMC oral health 2024-12, Vol.24 (1), p.1536-9, Article 1536
• Main Authors: Birant, Sinem, İlisulu, Sabiha Ceren, Ozcan, Hazal, Yanar, Karolin
• Format: Article
• Language: English
• Subjects: Acids; Advanced glycosylation end products; Antioxidant; Antioxidants; Antioxidants - analysis; Antioxidants - therapeutic use; Biofilms; Biological markers; Biomarkers; Biomarkers - analysis; Care and treatment; Cariostatic Agents - therapeutic use; Case-Control Studies; Child, Preschool; Children; Correlation analysis; Dental caries; Dental Caries - prevention & control; Diagnosis; Diseases; DMF Index; Early childhood caries; Female; Fluoride; Fluoride treatment; Fluoride treatments; Fluorides; Fluorides, Topical - therapeutic use; Free radicals; Health aspects; Humans; Hypotheses; Lipid peroxidation; Lipids; Male; Measurement; Methods; Microbiomes; Oxidation; Oxidative stress; Oxidative Stress - drug effects; Patient outcomes; Pediatric research; Proteins; Saliva; Saliva - chemistry; Saliva - metabolism; Salivary diagnostics; Superoxide dismutase; Systemic diseases
• ISSN: 1472-6831; 1472-6831
• DOI: 10.1186/s12903-024-05185-7

Saliva contains a variety of biochemical compounds, including antioxidants, and serves as the body's first line of defense against oxidative stress caused by free radicals. The aim of this study was to investigate the effects of dental treatments on salivary oxidative stress biomarkers in children aged 3-5 years with severe early childhood caries (S-ECC) compared to children without caries. This study was conducted on 20 children aged 3-5 years with severe early childhood caries (S-ECC) and 20 children without caries. Salivary oxidative stress biomarkers and antioxidants were measured after the initial examination (T0), after the end of restorative treatments (T1), and after fluoride varnish applications (T2). Post hoc Bonferroni test was used to compare normally distributed parameters between T0-T1-T2 times. Pearson correlation analysis was used to examine the relationships between parameters that conform to normal distribution. The Mann-Whitney U test was used to compare the parameters in the control and experimental groups. Significance was evaluated at the p