Regeneration of Thyroid Glands in the Spleen Restores Homeostasis in Thyroidectomy Mice

Surgical removal of the thyroid gland (TG) for treating thyroid disorders leaves the patients on lifelong hormone replacement that partially compensates the physiological needs, but regenerating TG is challenging. Here, an approach is reported to regenerate TG within the spleen for fully restoring t...

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Bibliographic Details
Published in:Advanced science 2024-02, Vol.11 (6), p.e2305913-n/a
Main Authors: Tian, Xue‐Jiao, Yin, Zhi‐Jie, Li, Zhen‐Jiang, Wang, Zhen‐Zhen, Xing, Zhen, Liu, Chun‐Yan, Wang, Lin‐Tao, Wang, Chun‐Ming, Zhang, Jun‐Feng, Dong, Lei
Format: Article
Language:English
Subjects:
Follicles
Growth factors
homeostasis restoration
Hormones
Lasers
Physiology
Skin & tissue grafts
Spleen
Thyroid cancer
thyroid regeneration
Thyroidectomy
Transplants & implants
Variance analysis
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Summary:Surgical removal of the thyroid gland (TG) for treating thyroid disorders leaves the patients on lifelong hormone replacement that partially compensates the physiological needs, but regenerating TG is challenging. Here, an approach is reported to regenerate TG within the spleen for fully restoring the thyroid's functions in mice, by transplanting thyroid tissue blocks to the spleen. Within 48 h, the transplanted tissue efficiently revascularizes, forming thyroid follicles similar to the native gland after 4 weeks. Structurally, the ectopically generated thyroid integrates with the surrounding splenic tissue while maintaining its integrity, separate from the lymphatic tissue. Functionally, it fully restores the native functions of the TG in hormone regulation in response to physiological stimuli, outperforming the established method of oral levothyroxine therapy in maintaining systemic homeostasis. The study demonstrates the full restoration of thyroid functions post‐thyroidectomy by intrasplenic TG regeneration, providing fresh insights for designing novel therapies for thyroid‐related disorders. The intrasplenic transplanted thyroid tissue blocks undergo angio‐follicular unit (AFU) reconstruction, epithelial and follicular regeneration, and finally, a regenerated thyroid gland that is independent and seamlessly integrated with the spleen taking advantage of the abundant vascularity of the spleen and the diversity of growth factors. The regenerated intrasplenic thyroid achieves precise hormone release and synthesis, fully restoring all thyroid functions.
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.202305913