Structurally diverse bufadienolides from the skins of Bufo bufo gargarizans and their cytotoxicity

Natural products, with their extensive chemical diversity, distinctive biological activities, and vast reservoirs, provide a robust foundation for advancing cancer therapeutics. A comprehensive phytochemical investigation of the skins from Bufo bufo gargarizans afforded two new bufadienolide derivat...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2024-11, Vol.14 (1), p.27344-10, Article 27344
Main Authors: Meng, Lingjie, Cao, Qian, Du, Xinyi, Lv, Huijing, Li, Chengjin, Zhang, Xiaoke, Jiang, Nian, Xiao, Yi
Format: Article
Language:English
Subjects:
639/638/309
639/638/45
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Bufalactamide A
Bufalactamide B
Bufanolides - chemistry
Bufanolides - pharmacology
Bufo bufo
Bufo bufo gargarizans
Cancer
Cell Line, Tumor
Colon cancer
Cytotoxic activity
Cytotoxicity
Humanities and Social Sciences
Humans
Liver cancer
Lung cancer
Molecular Structure
multidisciplinary
Natural products
Ovarian cancer
Science
Science (multidisciplinary)
Skin - drug effects
Structural elucidation
Structure-activity relationships
Toads
Tumor cell lines
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Natural products, with their extensive chemical diversity, distinctive biological activities, and vast reservoirs, provide a robust foundation for advancing cancer therapeutics. A comprehensive phytochemical investigation of the skins from Bufo bufo gargarizans afforded two new bufadienolide derivatives identified as bufalactamides A and B ( 1–2 ), along with six known compounds: argentinogenin (3) , desacetylcinobufagin ( 4 ), desacetylcinobufaginol ( 5 ), cinobufaginol ( 6 ), bufalin ( 7 ) and gamabufalin ( 8 ). The structural elucidation of these compounds was meticulously carried out by analyses of spectroscopic data (1D and 2D NMR, HR-ESIMS), and comparison with the literature data. Plausible biosynthetic pathways for the new compounds were also discussed. Moreover, the cytotoxicity of the compounds was investigated using various cancer cell lines, including lung cancer (A549), colon cancer (HCT-116), liver cancer (SK-Hep-1), and ovarian cancer (SKOV3). Our research findings indicated that compounds 3 , and 6 – 8 exhibit potent cytotoxic activity (IC 50  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-79194-5