Complex-Forming Properties of the Anti-Inflammatory Sialorphin Derivative Palmitic Acid-Lysine-Lysine-Glutamine-Histidine-Asparagine-Proline-Arginine with Cu(II) Ions in an Aqueous Solution

The present work describes the complexation of the anti-inflammatory sialorphin derivative Pal-Lys-Lys-Gln-His-Asn-Pro-Arg (palmitic acid-lysine-lysine-glutamine-histidine-asparagine-proline-arginine) with Cu(II) ions in an aqueous solution, at a temperature of 25.0 ± 0.1 °C, over the whole pH range...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2023-12, Vol.29 (1), p.90
Main Authors: Pająk, Marek, Kamysz, Elżbieta, Sikora, Karol, Fichna, Jakub, Woźniczka, Magdalena
Format: Article
Language:English
Subjects:
Amino acids
Anti-inflammatory drugs
Aqueous solutions
Cholesterol
Cu(II) complexes
Edema
Enkephalins
Fatty acids
High density lipoprotein
Inflammation
Ligands
Narcotics
Natriuretic peptides
palmitic acid
Peptides
Physiology
potentiometry
protonation constant
Saturated fatty acids
sialorphin
Spectrum analysis
Triglycerides
UV-Vis spectroscopy
Vegetable oils
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Kamysz, Elżbieta
Sikora, Karol
Fichna, Jakub
Woźniczka, Magdalena
description The present work describes the complexation of the anti-inflammatory sialorphin derivative Pal-Lys-Lys-Gln-His-Asn-Pro-Arg (palmitic acid-lysine-lysine-glutamine-histidine-asparagine-proline-arginine) with Cu(II) ions in an aqueous solution, at a temperature of 25.0 ± 0.1 °C, over the whole pH range. The complexing properties were characterized by potentiometric and UV-Vis spectrophotometric methods. The potentiometric method was used to calculate the logarithms of the overall stability constants (log ) and the values of the stepwise dissociation constants (p ) of the studied complexes. The percentage of each species formed in an aqueous solution was estimated from the species distribution curve as a function of pH. The absorbance ( ) and molar absorption coefficient ( ) values for the Cu(II)-sialorphin derivative system were determined with UV-Vis spectroscopy. Our studies indicate that the sialorphin derivative forms stable complexes with Cu(II) ions, which may lead to future biological and therapeutic applications.
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The complexing properties were characterized by potentiometric and UV-Vis spectrophotometric methods. The potentiometric method was used to calculate the logarithms of the overall stability constants (log ) and the values of the stepwise dissociation constants (p ) of the studied complexes. The percentage of each species formed in an aqueous solution was estimated from the species distribution curve as a function of pH. The absorbance ( ) and molar absorption coefficient ( ) values for the Cu(II)-sialorphin derivative system were determined with UV-Vis spectroscopy. Our studies indicate that the sialorphin derivative forms stable complexes with Cu(II) ions, which may lead to future biological and therapeutic applications.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules29010090</identifier><identifier>PMID: 38202673</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Amino acids ; Anti-inflammatory drugs ; Aqueous solutions ; Cholesterol ; Cu(II) complexes ; Edema ; Enkephalins ; Fatty acids ; High density lipoprotein ; Inflammation ; Ligands ; Narcotics ; Natriuretic peptides ; palmitic acid ; Peptides ; Physiology ; potentiometry ; protonation constant ; Saturated fatty acids ; sialorphin ; Spectrum analysis ; Triglycerides ; UV-Vis spectroscopy ; Vegetable oils</subject><ispartof>Molecules (Basel, Switzerland), 2023-12, Vol.29 (1), p.90</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. 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The complexing properties were characterized by potentiometric and UV-Vis spectrophotometric methods. The potentiometric method was used to calculate the logarithms of the overall stability constants (log ) and the values of the stepwise dissociation constants (p ) of the studied complexes. The percentage of each species formed in an aqueous solution was estimated from the species distribution curve as a function of pH. The absorbance ( ) and molar absorption coefficient ( ) values for the Cu(II)-sialorphin derivative system were determined with UV-Vis spectroscopy. 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subjects Amino acids
Anti-inflammatory drugs
Aqueous solutions
Cholesterol
Cu(II) complexes
Edema
Enkephalins
Fatty acids
High density lipoprotein
Inflammation
Ligands
Narcotics
Natriuretic peptides
palmitic acid
Peptides
Physiology
potentiometry
protonation constant
Saturated fatty acids
sialorphin
Spectrum analysis
Triglycerides
UV-Vis spectroscopy
Vegetable oils
title Complex-Forming Properties of the Anti-Inflammatory Sialorphin Derivative Palmitic Acid-Lysine-Lysine-Glutamine-Histidine-Asparagine-Proline-Arginine with Cu(II) Ions in an Aqueous Solution
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