Impact of Drp1-Mediated Mitochondrial Dynamics on T Cell Immune Modulation

In recent years, various breakthroughs have been made in tumor immunotherapy that have contributed to prolonging the survival of tumor patients. However, only a subset of patients respond to immunotherapy, which limits its use. One reason for this is that the tumor microenvironment (TME) hinders the...

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Published in:Frontiers in immunology 2022-03, Vol.13, p.873834-873834
Main Authors: Song, Jun, Yi, Xiaofang, Gao, Ruolin, Sun, Li, Wu, Zhixuan, Zhang, Shuling, Huang, Letian, Han, Chengbo, Ma, Jietao
Format: Article
Language:English
Subjects:
dynamin-related protein 1
Dynamins - metabolism
Humans
Immunology
immunotherapy
Mitochondria - metabolism
Mitochondrial Dynamics
Neoplasms - metabolism
Neoplasms - therapy
T cell exhaustion
T-Lymphocytes
Tumor Microenvironment
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Summary:In recent years, various breakthroughs have been made in tumor immunotherapy that have contributed to prolonging the survival of tumor patients. However, only a subset of patients respond to immunotherapy, which limits its use. One reason for this is that the tumor microenvironment (TME) hinders the migration and infiltration of T cells and affects their continuous functioning, resulting in an exhausted phenotype. Therefore, clarifying the mechanism by which T cells become exhausted is of significance for improving the efficacy of immunotherapy. Several recent studies have shown that mitochondrial dynamics play an important role in the immune surveillance function of T cells. Dynamin-related protein 1 (Drp1) is a key protein that mediates mitochondrial fission and maintains the mitochondrial dynamic network. Drp1 regulates various activities of T cells by mediating the activation of a series of pathways. In addition, abnormal mitochondrial dynamics were observed in exhausted T cells in the TME. As a potential target for immunotherapy, in this review, we describe in detail how Drp1 regulates various physiological functions of T cells and induces changes in mitochondrial dynamics in the TME, providing a theoretical basis for further research.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.873834