Functional and structural reverse myocardial remodeling following transcatheter aortic valve replacement: a prospective cardiovascular magnetic resonance study

• Published in: Journal of cardiovascular magnetic resonance 2022-07, Vol.24 (1), p.45-45, Article 45
• Main Authors: Lange, Torben, Backhaus, Sören J, Beuthner, Bo Eric, Topci, Rodi, Rigorth, Karl-Rudolf, Kowallick, Johannes T, Evertz, Ruben, Schnelle, Moritz, Ravassa, Susana, Díez, Javier, Toischer, Karl, Seidler, Tim, Puls, Miriam, Hasenfuß, Gerd, Schuster, Andreas
• Format: Article
• Language: English
• Subjects: Aorta; Aortic stenosis; Aortic valve; Aortic Valve - diagnostic imaging; Aortic Valve - pathology; Aortic Valve - surgery; Aortic valve stenosis; Aortic Valve Stenosis - diagnostic imaging; Aortic Valve Stenosis - pathology; Aortic Valve Stenosis - surgery; Assessment of myocardial function and structure; Biomarkers; Cardiac magnetic resonance imaging; Cardiac patients; Collagen; Congestive heart failure; Contrast Media; Fibrosis; Gadolinium; Heart; Heart Failure; Heart valves; Humans; Imaging; Ischemia; Laboratories; Magnetic resonance; Magnetic resonance imaging; Magnetic Resonance Spectroscopy; Medical imaging; Medical research; Medicine, Experimental; Myocardial remodeling; Normal distribution; Patients; Population; Predictive Value of Tests; Prospective Studies; Quality of life; Regression analysis; Resonance; Software; Stroke Volume; Structure-function relationships; Therapeutic targets; Transcatheter aortic valve replacement; Transcatheter Aortic Valve Replacement - adverse effects; Treatment Outcome; Values; Ventricle; Ventricular Function, Left; Ventricular Remodeling
• ISSN: 1097-6647; 1532-429X
• DOI: 10.1186/s12968-022-00874-0

Since cardiovascular magnetic resonance (CMR) imaging allows comprehensive quantification of both myocardial function and structure we aimed to assess myocardial remodeling processes in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). CMR imaging was performed in 40 patients with severe AS before and 1 year after TAVR. Image analyses comprised assessments of myocardial volumes, CMR-feature-tracking based atrial and ventricular strain, myocardial T1 mapping, extracellular volume fraction-based calculation of left ventricular (LV) cellular and matrix volumes, as well as ischemic and non-ischemic late gadolinium enhancement analyses. Moreover, biomarkers including NT-proBNP as well as functional and clinical status were documented. Myocardial function improved 1 year after TAVR: LV ejection fraction (57.9 ± 16.9% to 65.4 ± 14.5%, p = 0.002); LV global longitudinal (- 21.4 ± 8.0% to -25.0 ± 6.4%, p