Progress in SARS-CoV-2, diagnostic and clinical treatment of COVID-19

Corona Virus Disease 2019(COVID-19)is a global pandemic novel coronavirus infection disease caused by Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). Although rapid, large-scale testing plays an important role in patient management and slowing the spread of the disease. However, there...

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Bibliographic Details
Published in:Heliyon 2024-06, Vol.10 (12), p.e33179, Article e33179
Main Authors: Li, Yang, Lu, Si-Ming, Wang, Jia-Long, Yao, Hang-Ping, Liang, Li-Guo
Format: Article
Language:English
Subjects:
COVID-19
Diagnosis
Pharmacological treatment
Review
SARS-CoV-2
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Summary:Corona Virus Disease 2019(COVID-19)is a global pandemic novel coronavirus infection disease caused by Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). Although rapid, large-scale testing plays an important role in patient management and slowing the spread of the disease. However, there has been no good and widely used drug treatment for infection and transmission of SARS-CoV-2. Therefore, this review updates the body of knowledge on viral structure, infection routes, detection methods, and clinical treatment, with the aim of responding to the large-section caused by SARS-CoV-2. This paper focuses on the structure of SARS-CoV-2 viral protease, RNA polymerase, serine protease and main proteinase-like protease as well as targeted antiviral drugs. In vitro or clinical trials have been carried out to provide deeper thinking for the pathogenesis, clinical diagnosis, vaccine development and treatment of SARS-CoV-2.
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e33179