Exploration of the novel fluoroquinolones with high inhibitory effect against quinolone-resistant DNA gyrase of Salmonella Typhimurium

Quinolone-resistant nontyphoidal is a pressing public health concern, demanding the exploration of novel treatments. In this study, we focused on two innovative synthetic fluoroquinolones, WQ-3034 and WQ-3154. Our findings revealed that these new compounds demonstrate potent inhibitory effects, even...

Full description

Saved in:
Bibliographic Details
Published in:Microbiology spectrum 2023-12, Vol.11 (6), p.e0133023-e0133023
Main Authors: Toyting, Jirachaya, Miura, Nami, Utrarachkij, Fuangfa, Tanomsridachchai, Wimonrat, Belotindos, Lawrence P, Suwanthada, Pondpan, Kapalamula, Thoko Flav, Kongsoi, Siriporn, Koide, Kentaro, Kim, Hyun, Thapa, Jeewan, Nakajima, Chie, Suzuki, Yasuhiko
Format: Article
Language:English
Subjects:
Antimicrobial Chemotherapy
DNA gyrase
fluoroquinolones
Research Article
Salmonella Typhimurium
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Quinolone-resistant nontyphoidal is a pressing public health concern, demanding the exploration of novel treatments. In this study, we focused on two innovative synthetic fluoroquinolones, WQ-3034 and WQ-3154. Our findings revealed that these new compounds demonstrate potent inhibitory effects, even against mutant strains that cause resistance to existing quinolones. Hence, WQ-3034 and WQ-3154 could potentially be effective therapeutic agents against quinolone-resistant Typhimurium. Furthermore, the data obtained in this study will be baseline information for antimicrobial drug development.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.01330-23