Management of Candida infections in liver transplant recipients: current perspectives

Liver transplantation has emerged as a widely accepted lifesaving therapeutic option for many patients with a variety of liver diseases. Improved surgical and medical management has led to significant improvements in post-transplant survival rates with a 1 year and 5 year patient survival of 87% and...

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Bibliographic Details
Published in:Transplant research and risk management 2014-01, Vol.6 (default), p.45-53
Main Authors: Lingegowda, Pushpalatha B, Tan, Ban Hock
Format: Article
Language:English
Subjects:
Analysis
Care and treatment
Diagnosis
Epidemiology
Liver
Liver transplantation
Mortality
Mycoses
Pathogenic microorganisms
Patient safety
Prevention
Statistics
United States
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Summary:Liver transplantation has emerged as a widely accepted lifesaving therapeutic option for many patients with a variety of liver diseases. Improved surgical and medical management has led to significant improvements in post-transplant survival rates with a 1 year and 5 year patient survival of 87% and 73%, respectively. A high mortality rate due to infections during the first post-transplant year persists. Invasive candidiasis is recognized as a significant problem associated with high morbidity and mortality. Recent surveillance data has helped to understand the changes in the epidemiology and the evolving trends in the use of antifungal agents for prophylaxis and treatment combined with the challenges of managing these invasive fungal infections, which has led the transplant community to explore the best management strategies. The emergence of resistant fungi and excess costs in managing these invasive fungal infections has added to the complexities of management. In this context, current perspectives in the management of Candida infections in liver transplant recipients will be reviewed. Keywords: Candida infections, management, liver transplant
ISSN:1179-1616
1179-1616
DOI:10.2147/TRRM.S38620