Innate immunity and HPV: friends or foes

Most human papillomavirus infections are readily cleared by the host immune response. However, in some individuals, human papillomavirus can establish a persistent infection. The persistence of high-risk human papillomavirus infection is the major risk factor for cervical cancer development. These v...

Full description

Saved in:
Bibliographic Details
Published in:Clinics (São Paulo, Brazil) Brazil), 2018-01, Vol.73 (suppl 1), p.e549s, Article e549s
Main Authors: Nunes, Rafaella Almeida Lima, Morale, Mirian Galliote, Silva, Gabriela Ávila Fernandes, Villa, Luisa Lina, Termini, Lara
Format: Article
Language:English
Subjects:
Cell Transformation, Neoplastic
Cervical Cancer
Disease Progression
Female
Human Papillomavirus
Humans
Immune Evasion
Immunity, Innate - immunology
Innate Immune System
MEDICINE, GENERAL & INTERNAL
Papillomaviridae - immunology
Papillomavirus Infections - virology
Review
Uterine Cervical Neoplasms - virology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Most human papillomavirus infections are readily cleared by the host immune response. However, in some individuals, human papillomavirus can establish a persistent infection. The persistence of high-risk human papillomavirus infection is the major risk factor for cervical cancer development. These viruses have developed mechanisms to evade the host immune system, which is an important step in persistence and, ultimately, in tumor development. Several cell types, receptors, transcription factors and inflammatory mediators involved in the antiviral immune response are viral targets and contribute to tumorigenesis. These targets include antigen-presenting cells, macrophages, natural killer cells, Toll-like receptors, nuclear factor kappa B and several cytokines and chemokines, such as interleukins, interferon and tumor necrosis factor. In the present review, we address both the main innate immune response mechanisms involved in HPV infection clearance and the viral strategies that promote viral persistence and may contribute to cancer development. Finally, we discuss the possibility of exploiting this knowledge to develop effective therapeutic strategies.
ISSN:1807-5932
1980-5322
1980-5322
DOI:10.6061/clinics/2018/e549s