Potential Role of Mic60/Mitofilin in Parkinson's Disease

There are currently no treatments that hinder or halt the inexorable progression of Parkinson's disease (PD). While the etiology of PD remains elusive, evidence suggests that early dysfunction of mitochondrial respiration and homeostasis play a major role in PD pathogenesis. The mitochondrial s...

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Bibliographic Details
Published in:Frontiers in neuroscience 2019-01, Vol.12, p.898-898
Main Authors: Van Laar, Victor S, Otero, P Anthony, Hastings, Teresa G, Berman, Sarah B
Format: Article
Language:English
Subjects:
Disease
Etiology
Homeostasis
Mic60/mitofilin
Mitochondria
mitochondrial dynamics
Morphology
Movement disorders
Neurodegeneration
Neurodegenerative diseases
Neurological diseases
Neuroscience
Oxidative stress
Parkinson's disease
Pathogenesis
Pathology
Phosphorylation
Proteins
Respiration
Therapeutic applications
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Summary:There are currently no treatments that hinder or halt the inexorable progression of Parkinson's disease (PD). While the etiology of PD remains elusive, evidence suggests that early dysfunction of mitochondrial respiration and homeostasis play a major role in PD pathogenesis. The mitochondrial structural protein Mic60, also known as mitofilin, is critical for maintaining mitochondrial architecture and function. Loss of Mic60 is associated with detrimental effects on mitochondrial homeostasis. Growing evidence now implicates Mic60 in the pathogenesis of PD. In this review, we discuss the data supporting a role of Mic60 and mitochondrial dysfunction in PD. We will also consider the potential of Mic60 as a therapeutic target for treating neurological disorders.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2018.00898