The role of different SIRT1-mediated signaling pathways in toxic injury

Common environmental pollutants and drugs encountered in everyday life can cause toxic damage to the body through oxidative stress, inflammatory stimulation, induction of apoptosis, and inhibition of energy metabolism. Silent information regulator 1 (SIRT1), a nicotinamide adenine dinucleotide-depen...

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Bibliographic Details
Published in:Cellular & molecular biology letters 2019-05, Vol.24 (1), p.36-36, Article 36
Main Authors: Ren, Zhihua, He, Hongyi, Zuo, Zhicai, Xu, Zhiwen, Wei, Zhanyong, Deng, Junliang
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animals
Antioxidants
Apoptosis
Cadmium
Cardiotoxicity
Cell cycle
Cytoplasm
DNA damage
Energy metabolism
Fluorides
Gene expression
Hazardous materials
Humans
Inflammation
Metabolism
Mitochondria
Models, Biological
NAD
Nervous system
Neuroprotection
Oxidative metabolism
Oxidative stress
Protein expression
Proteins
Radiation
Review
Senescence
Signal transduction
Signal Transduction - drug effects
Signaling pathway
SIRT1
SIRT1 activator
SIRT1 protein
Sirtuin 1 - metabolism
Toxicant
Toxicants
Toxins, Biological - toxicity
Transcription factors
Tumor necrosis factor-TNF
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Summary:Common environmental pollutants and drugs encountered in everyday life can cause toxic damage to the body through oxidative stress, inflammatory stimulation, induction of apoptosis, and inhibition of energy metabolism. Silent information regulator 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent deacetylase, is a member of the evolutionarily highly conserved Sir2 (silent information regulator 2) superprotein family, which is located in the nucleus and cytoplasm. It can deacetylate protein substrates in various signal transduction pathways to regulate gene expression, cell apoptosis and senescence, participate in the process of neuroprotection, energy metabolism, inflammation and the oxidative stress response in living organisms, and plays an important role in toxic damage caused by toxicants and in the process of SIRT1 activator/inhibitor antagonized toxic damage. This review summarizes the role that SIRT1 plays in toxic damage caused by toxicants via its interactions with protein substrates in certain signaling pathways.
ISSN:1425-8153
1689-1392
DOI:10.1186/s11658-019-0158-9