Mapping circulating serum miRNAs to their immune-related target mRNAs

Evidence suggests that circulating serum microRNAs (miRNAs) might preferentially target immune-related mRNAs. If this were the case, we hypothesized that immune-related mRNAs would have more predicted serum miRNA binding sites than other mRNAs and, reciprocally, that serum miRNAs would have more imm...

Full description

Saved in:
Bibliographic Details
Published in:Advances and applications in bioinformatics and chemistry 2017, Vol.10, p.1-9
Main Authors: Nosirov, Bakhtiyor, Billaud, Joël, Vandenbon, Alexis, Diez, Diego, Wijaya, Edward, Ishii, Ken J, Teraguchi, Shunsuke, Standley, Daron M
Format: Article
Language:English
Subjects:
Binding sites
biomarker
Biomarkers
Cancer
Gene expression
Genomics
Identification
Immune system
Immunology
Messenger RNA
MicroRNA
MicroRNAs
Original Research
post-transcriptional regulation
Prejudice
Random Forest
RNA
target prediction
Target recognition
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Evidence suggests that circulating serum microRNAs (miRNAs) might preferentially target immune-related mRNAs. If this were the case, we hypothesized that immune-related mRNAs would have more predicted serum miRNA binding sites than other mRNAs and, reciprocally, that serum miRNAs would have more immune-related mRNA targets than non-serum miRNAs. We developed a consensus target predictor using the random forest framework and calculated the number of predicted miRNA-mRNA interactions in various subsets of miRNAs (serum, non-serum) and mRNAs (immune related, nonimmune related). Immune-related mRNAs were predicted to be targeted by serum miRNA more than other mRNAs. Moreover, serum miRNAs were predicted to target many more immune-related mRNA targets than non-serum miRNAs; however, these two biases in immune-related mRNAs and serum miRNAs appear to be completely independent. Immune-related mRNAs have more miRNA binding sites in general, not just for serum miRNAs; likewise, serum miRNAs target many more mRNAs than non-serum miRNAs overall, regardless of whether they are immune related or not. Nevertheless, these two independent phenomena result in a significantly larger number of predicted serum miRNA-immune mRNA interactions than would be expected by chance.
ISSN:1178-6949
1178-6949
DOI:10.2147/AABC.S121598