T2∗ magnetic resonance imaging: A non-invasive biomarker of brain iron content in children with attention-deficit/hyperactivity disorder

The aims of this study were the followings: First: To compare brain iron content in children with Attention-Deficit/Hyperactivity Disorder (ADHD) and healthy control subjects, estimated by T2∗ MRI value and its reciprocal R2∗. Second: To assess the association between brain iron content and distinct...

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Bibliographic Details
Published in:Egyptian journal of radiology and nuclear medicine 2017-03, Vol.48 (1), p.161-167
Main Authors: Hasaneen, Bothina Mohamed, Sarhan, Mohamed, Samir, Sieza, ELAssmy, Mohamed, Sakrana, Amal A., Ashamalla, Germeen Albair
Format: Article
Language:English
Subjects:
ADHD
Brain iron
R2∗ measurements
T2∗-MRI
Thalamus
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Summary:The aims of this study were the followings: First: To compare brain iron content in children with Attention-Deficit/Hyperactivity Disorder (ADHD) and healthy control subjects, estimated by T2∗ MRI value and its reciprocal R2∗. Second: To assess the association between brain iron content and distinct types of ADHD (predominantly inattentive, predominantly hyperactive/impulsive, or combined). Third: To test the ability of T2∗ MRI to grade the severity of ADHD. 35 children (17 ADHD patients and 18 healthy non-ADHD controls) underwent T2∗-MRI to assess brain iron content. R2∗ value is calculated for both thalami. ADHD group showed significantly lower R2∗ (mean 14.9s−1±1.3) value when compared to control group (mean R2∗ 16.6s−1±0.9) (p=
ISSN:0378-603X
DOI:10.1016/j.ejrnm.2016.08.001