The effect of prebiotic supplementation on serum levels of tryptophan and kynurenine in obese women with major depressive disorder: a double-blinded placebo-controlled randomized clinical trial

• Published in: BMC research notes 2024-10, Vol.17 (1), p.316-7, Article 316
• Main Authors: Khademi, Fatemeh, Tutunchi, Helda, Vaghef-Mehrabani, Elnaz, Ebrahimi-Mameghani, Mehrangiz
• Format: Article
• Language: English
• Subjects: Adult; Caloric Restriction - methods; Depressive Disorder, Major - blood; Depressive Disorder, Major - diet therapy; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - therapy; Diet therapy; Dietary Supplements; Double-Blind Method; Female; Health aspects; Humans; Inulin; Inulin - administration & dosage; Kynurenine (Kyn); Kynurenine - blood; Low-calorie diet; Major depressive disorder; Major depressive disorder (MDD); Measurement; Middle Aged; Obesity; Obesity - blood; Obesity - complications; Obesity - diet therapy; Obesity - therapy; Overweight persons; Patient outcomes; Prebiotics; Prebiotics - administration & dosage; Psychological aspects; Research Note; Social aspects; Tryptophan; Tryptophan (Trp); Tryptophan - blood
• ISSN: 1756-0500; 1756-0500
• DOI: 10.1186/s13104-024-06963-w

The objective of the present study was to examine the effect of calorie restricted diet (CRD) plus inulin supplementation on serum levels of tryptophan (Trp), kynurenine (Kyn) and Trp/Kyn ratio in obese women with major depressive disorder (MDD). In this double-blind placebo-controlled randomized clinical trial, 51 obese women (BMI = 30-40 kg/m ) with mild MDD were assessed for depression level using Hamilton depression rating scale (HDRS). The patients were randomly allocated into either "Prebiotic group" (received 10 g/day inulin) or "Placebo group" (received 10 g/day maltodextrin). All participants also received individualized CRD. Fasting serum levels of Trp, Kyn, and Trp/Kyn ratio were assessed at baseline and after 8 weeks. Results showed slightly greater increases in serum levels of Trp and Trp/Kyn ratio as well as reductions in serum level of Kyn and HDRS score in prebiotic group than placebo group. However, between group differences in these parameters as well as HDRS score were not statistically significant after adjusting for baseline variables at the end of the trial. Results indicates that CRD accompanied by inulin supplementation (10 g/day) did not influence serum levels of Trp, Kyn and Trp/Kyn ratio as well as HDRS score after 8 weeks. The trial was registered in the Iranian registry of clinical trials at 2018-08-02 ( https://www.irct.ir/ ; registration number: IRCT20100209003320N15).