A Systematic Review and Meta-Analysis of Molecular Characteristics on Colistin Resistance of Acinetobacter baumannii

This study aimed to determine the molecular epidemiology of colistin-resistant in the last ten years and the frequency of gene regions related to pathogenesis, to compare the methods used to detect genes, and to confirm colistin resistance. This meta-analysis study was conducted under Preferred Repo...

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Bibliographic Details
Published in:Diagnostics (Basel) 2024-11, Vol.14 (22), p.2599
Main Authors: Ciftci, Ihsan Hakki, Kahraman Kilbas, Elmas Pinar, Kilbas, Imdat
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Antibiotics
Bacteria
Colistin
colistin resistance
Data collection
Drug resistance
Epidemiology
Genes
Genetic engineering
Gram-negative bacteria
Lipids
mcr
Meta-analysis
Methods
Nosocomial infections
oxa
Oxalic acid
pmr
Systematic Review
Variance analysis
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Summary:This study aimed to determine the molecular epidemiology of colistin-resistant in the last ten years and the frequency of gene regions related to pathogenesis, to compare the methods used to detect genes, and to confirm colistin resistance. This meta-analysis study was conducted under Preferred Reporting Items for Systematic Reviews and Meta-Analysis Guidelines. In the meta-analysis, research articles published in English and Turkish in electronic databases between January 2012 and November 2023 were examined. International Business Machines (IBM) Statistical Package for the Social Sciences (SPSS) Statistics for Macbook (Version 25.0. Armonk, NY, USA) was used for statistical analysis. The Comprehensive Meta-Analysis (CMA) (Version 3.0. Biostat, NJ, USA) program was used for heterogeneity assessment in the articles included in the meta-analysis. After evaluating the studies according to the elimination criteria, 18 original articles were included. Among colistin-resistant strains, positivity was 243 (19.61%), was 113 (9.12%), was 7 (0.56%), was 15 (1.21%), and was seen in two (0.16%) strains. The positivity rates of , , and were found to be 22 (1.77%), 26 (2.09%), and 6 (0.48%). The rate was found to be 91 (7.34%), the rate was 78 (6.29%), and the rate was 82 (6.61%). The colistin resistance rate in our study was found to be high. However, only some research articles report and/or investigate more than one resistance gene together. Additionally, it may be challenging to explain colistin resistance solely by expressing resistance genes without discussing accompanying components such as efflux pumps, virulence factors, etc.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics14222599