YOUPI: Your powerful and intelligent tool for segmenting cells from imaging mass cytometry data

The recent emergence of imaging mass cytometry technology has led to the generation of an increasing amount of high-dimensional data and, with it, the need for suitable performant bioinformatics tools dedicated to specific multiparametric studies. The first and most important step in treating the ac...

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Bibliographic Details
Published in:Frontiers in immunology 2023-03, Vol.14, p.1072118-1072118
Main Authors: Scuiller, Yvonne, Hemon, Patrice, Le Rochais, Marion, Pers, Jacques-Olivier, Jamin, Christophe, Foulquier, Nathan
Format: Article
Language:English
Subjects:
Algorithms
cell segmentation
Image Cytometry
imaging mass cytometry
Immunology
new algorithm
Software
U-NET
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Summary:The recent emergence of imaging mass cytometry technology has led to the generation of an increasing amount of high-dimensional data and, with it, the need for suitable performant bioinformatics tools dedicated to specific multiparametric studies. The first and most important step in treating the acquired images is the ability to perform highly efficient cell segmentation for subsequent analyses. In this context, we developed YOUPI (Your Powerful and Intelligent tool) software. It combines advanced segmentation techniques based on deep learning algorithms with a friendly graphical user interface for non-bioinformatics users. In this article, we present the segmentation algorithm developed for YOUPI. We have set a benchmark with mathematics-based segmentation approaches to estimate its robustness in segmenting different tissue biopsies.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1072118