A Mendelian randomization study of genetic liability to post-traumatic stress disorder and risk of ischemic stroke

Observational studies have shown an association between post-traumatic stress disorder (PTSD) and ischemic stroke (IS) but given the susceptibility to confounding it is unclear if these associations represent causal effects. Mendelian randomization (MR) facilitates causal inference that is robust to...

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Published in:Translational psychiatry 2023-07, Vol.13 (1), p.237-237, Article 237
Main Authors: Soremekun, Opeyemi, Musanabaganwa, Clarisse, Uwineza, Annette, Ardissino, Maddalena, Rajasundaram, Skanda, Wani, Agaz H., Jansen, Stefan, Mutabaruka, Jean, Rutembesa, Eugene, Soremekun, Chisom, Cheickna, Cisse, Wele, Mamadou, Mugisha, Joseph, Nash, Oyekanmi, Kinyanda, Eugene, Nitsch, Dorothea, Fornage, Myriam, Chikowore, Tinashe, Gill, Dipender, Wildman, Derek E., Mutesa, Leon, Uddin, Monica, Fatumo, Segun
Format: Article
Language:English
Subjects:
45/43
631/208/1516
631/208/212
Behavioral Sciences
Biological Psychology
Consortia
Genome-Wide Association Study
Humans
Ischemic Stroke
Medicine
Medicine & Public Health
Mendelian Randomization Analysis
Neurosciences
Pharmacotherapy
Post traumatic stress disorder
Psychiatry
Stress Disorders, Post-Traumatic - genetics
Stroke - epidemiology
Stroke - genetics
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Summary:Observational studies have shown an association between post-traumatic stress disorder (PTSD) and ischemic stroke (IS) but given the susceptibility to confounding it is unclear if these associations represent causal effects. Mendelian randomization (MR) facilitates causal inference that is robust to the influence of confounding. Using two sample MR, we investigated the causal effect of genetic liability to PTSD on IS risk. Ancestry-specific genetic instruments of PTSD and four quantitative sub-phenotypes of PTSD, including hyperarousal, avoidance, re-experiencing, and total symptom severity score (PCL-Total) were obtained from the Million Veteran Programme (MVP) using a threshold P value ( P) of
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-023-02542-y