Measuring the impact of a single dose of ChAdOx1 nCoV-19 (recombinant) coronavirus vaccine on hospital stay, ICU requirement, and mortality outcome in a tertiary care centre

• Published in: International journal of infectious diseases 2021-12, Vol.113, p.282-287
• Main Authors: Desai, Anuja, Desai, Parth, Mehta, Jigar, Sachora, Wasimahmed, Bharti, Neeraj, Patel, Tushar, Sukhwani, Kalpesh, Jain, Ankita, Sorathiya, Dipesh, Nanda, Vivek, Mehta, Parin, Desai, Adit
• Format: Article
• Language: English
• Subjects: ChAdOx1 nCoV-19; ChAdOx1 nCoV-19 vaccine; COVID-19; COVID-19 Vaccines; Humans; Intensive Care Units; Length of Stay; Observational Studies as Topic; SARS-CoV-2; SARS-CoV-2 infection; Tertiary Care Centers; Vaccination; vaccine hesitancy
• ISSN: 1201-9712; 1878-3511; 1878-3511
• DOI: 10.1016/j.ijid.2021.10.032

•COVID-19 infection impact across the globe.•India's vaccination drive for COVID-19 in the second wave.•COVID-19 infection after a single vaccination dose.•Hospitalisation after single dose of COVID-19 vaccine.•Severity of COVID-19 infection post vaccination.•Reduced mortality in vaccinated patients. To comparatively evaluate ICU requirement, length of stay, and mortality between single-dose vaccinated and non-vaccinated hospitalized COVID-19 patients. A retrospective observational study was carried out in a tertiary care hospital in western Indian, from April 1 to June 30, 2021. Of the 569 patients who fulfilled the eligibility criteria and were enrolled in the study, 137 (24.08%) patients had received a single dose of ChAdOx1 nCoV-19 vaccine, while 432 (75.92%) patients had not received any form of vaccination. The overall length of stay in hospital was similar for both groups; however, a significant difference was seen in length of stay in the ward and in the ICU. Vaccinated patients were admitted to the ward for 6.21 ± 3.204 days, while non-vaccinated patients were admitted for 5.56 ± 4.55 days (p < 0.001). The mean length of ICU stay for the 21 vaccinated patients requiring intensive care was 4.47 ± 2.3 days, while that for the 145 non-vaccinated patients was 6.29 ± 2.19 days (p < 0.001). Mortality was observed in four patients in the vaccinated group and in 95 patients in the non-vaccinated group. A single dose of ChAdOx1 nCoV-19 vaccine was associated with a significantly lower severity of SARS-CoV-2 infection compared with no vaccination.