Synthesis of pyrimidines by Fe3O4@SiO2-L-proline nanoparticles

Fe @SiO -L-proline nanoparticles have been used as an effective catalyst for the preparation of pyrimidines by three-component reactions of 1,3-dimethylbarbituric acid, aromatic aldehydes and 4-methyl aniline or 4-methoxy aniline under reflux condition in ethanol. Fe @SiO -L-proline nanoparticles ha...

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Bibliographic Details
Published in:Main group metal chemistry 2020-01, Vol.43 (1), p.117-124
Main Authors: Safaei-Ghomi, Javad, Samadi, Zahra
Format: Article
Language:English
Subjects:
Aldehydes
Aniline
Catalysts
Ethanol
fe3o4 nanoparticles
Gravimetric analysis
heterogeneous catalyst
Infrared spectroscopy
Iron oxides
Nanoparticles
one-pot
Photon correlation spectroscopy
Proline
Pyrimidines
Silicon dioxide
Thermal analysis
X ray powder diffraction
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Summary:Fe @SiO -L-proline nanoparticles have been used as an effective catalyst for the preparation of pyrimidines by three-component reactions of 1,3-dimethylbarbituric acid, aromatic aldehydes and 4-methyl aniline or 4-methoxy aniline under reflux condition in ethanol. Fe @SiO -L-proline nanoparticles have been characterized by scanning electronic microscopy (SEM), powder X-ray diffraction (XRD), vibrating sample magnetometer (VSM), thermal gravimetric analysis (TGA), energy dispersive X-ray (EDS), dynamic light scattering (DLS) and FT-IR spectroscopy. This method provides several advantages including, the reusability of the catalyst, low catalyst loading, atom economy, short reaction times and high yields of products.
ISSN:0792-1241
2191-0219
DOI:10.1515/mgmc-2020-0014