Types of neural guides and using nanotechnology for peripheral nerve reconstruction

Peripheral nerve injuries can lead to lifetime loss of function and permanent disfigurement. Different methods, such as conventional allograft procedures and use of biologic tubes present problems when used for damaged peripheral nerve reconstruction. Designed scaffolds comprised of natural and synt...

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Bibliographic Details
Published in:International journal of nanomedicine 2010-01, Vol.5 (default), p.839-852
Main Authors: Biazar, Esmaeil, Khorasani, M T, Montazeri, Naser, Pourshamsian, Khalil, Daliri, Morteza, Rezaei, Mostafa, Jabarvand, Mahmoud, Khoshzaban, Ahad, Heidari, Saeed, Jafarpour, Mostafa, Roviemiab, Ziba
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - therapeutic use
Cell adhesion & migration
Guided Tissue Regeneration - methods
Humans
nanofibers
Nanofibers - therapeutic use
Nanomedicine - methods
Nanotechnology
Nanotechnology - methods
nerve reconstruction
Nerve Regeneration - physiology
Nerve Transfer
neural guide
Peripheral Nerve Injuries
Peripheral Nerves - physiopathology
Review
Tissue Scaffolds - chemistry
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Summary:Peripheral nerve injuries can lead to lifetime loss of function and permanent disfigurement. Different methods, such as conventional allograft procedures and use of biologic tubes present problems when used for damaged peripheral nerve reconstruction. Designed scaffolds comprised of natural and synthetic materials are now widely used in the reconstruction of damaged tissues. Utilization of absorbable and nonabsorbable synthetic and natural polymers with unique characteristics can be an appropriate solution to repair damaged nerve tissues. Polymeric nanofibrous scaffolds with properties similar to neural structures can be more effective in the reconstruction process. Better cell adhesion and migration, more guiding of axons, and structural features, such as porosity, provide a clearer role for nanofibers in the restoration of neural tissues. In this paper, basic concepts of peripheral nerve injury, types of artificial and natural guides, and methods to improve the performance of tubes, such as orientation, nanotechnology applications for nerve reconstruction, fibers and nanofibers, electrospinning methods, and their application in peripheral nerve reconstruction are reviewed.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S11883